Acetaminophen for osteoarthritis

Management of Osteoarthritis

“…In Poolsup and associates, 52 the risk of disease progression was reduced by 54% (pooled RR, 0.46; 95% CI, 0.28-0.73; P = 0.0011). The number needed to treat was nine (95% CI, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Similar results were described by Richy and colleagues, 53 who showed significant efficacy of glucosamine on joint space narrowing with an effect size of 0.41 (95% CI, 0.21-0.60; P < 0.001), which corresponds to a low to medium effect.…”

Management of Osteoarthritis

“…In Poolsup and associates, 52 the risk of disease progression was reduced by 54% (pooled RR, 0.46; 95% CI, 0.28-0.73; P = 0.0011). The number needed to treat was nine (95% CI, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Similar results were described by Richy and colleagues, 53 who showed significant efficacy of glucosamine on joint space narrowing with an effect size of 0.41 (95% CI, 0.21-0.60; P < 0.001), which corresponds to a low to medium effect.…”

Glucosamine sulphate: an umbrella review of health outcomes

“…59 Given this, the effect of GS, compared with placebo, is ranked between small and moderate. However, as already discussed in other relevant papers, 7,11 these effects are almost doubled those of paracetamol, 60 a common medication used for knee OA pain-relief treatment. Moreover, other medications commonly used for the treatment of knee OA have a similar effect as observed for GS, as indicated in the recent network meta-analysis of Gregori et al in which GS and celecoxib were the only long-term OA treatments associated with pain reduction [effect size (ES) = 0.29 and ES = 0.18, respectively].…”

An interpretable boosting model to predict side effects of analgesics for osteoarthritis

“…It is well known that blood pressure is closely related to cardiovascular disease, blood pressure is a secondary risk factor in that blood pressure pills may increase the risk [9, 10], the analgesics can have a direct side effect on blood pressure. For patients with abnormal blood pressure, they should be careful in using analgesics.…”

Management of Osteoarthritis

“…In Poolsup and associates, 52 the risk of disease progression was reduced by 54% (pooled RR, 0.46; 95% CI, 0.28-0.73; P = 0.0011). The number needed to treat was nine (95% CI, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Similar results were described by Richy and colleagues, 53 who showed significant efficacy of glucosamine on joint space narrowing with an effect size of 0.41 (95% CI, 0.21-0.60; P < 0.001), which corresponds to a low to medium effect.…”

Glucosamine sulphate: an umbrella review of health outcomes

“…59 Given this, the effect of GS, compared with placebo, is ranked between small and moderate. However, as already discussed in other relevant papers, 7,11 these effects are almost doubled those of paracetamol, 60 a common medication used for knee OA pain-relief treatment. Moreover, other medications commonly used for the treatment of knee OA have a similar effect as observed for GS, as indicated in the recent network meta-analysis of Gregori et al in which GS and celecoxib were the only long-term OA treatments associated with pain reduction [effect size (ES) = 0.29 and ES = 0.18, respectively].…”

An interpretable boosting model to predict side effects of analgesics for osteoarthritis

“…It is well known that blood pressure is closely related to cardiovascular disease, blood pressure is a secondary risk factor in that blood pressure pills may increase the risk [9, 10], the analgesics can have a direct side effect on blood pressure. For patients with abnormal blood pressure, they should be careful in using analgesics.…”

Management of Osteoarthritis

“…In Poolsup and associates, 52 the risk of disease progression was reduced by 54% (pooled RR, 0.46; 95% CI, 0.28-0.73; P = 0.0011). The number needed to treat was nine (95% CI, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Similar results were described by Richy and colleagues, 53 who showed significant efficacy of glucosamine on joint space narrowing with an effect size of 0.41 (95% CI, 0.21-0.60; P < 0.001), which corresponds to a low to medium effect.…”

Glucosamine sulphate: an umbrella review of health outcomes

“…59 Given this, the effect of GS, compared with placebo, is ranked between small and moderate. However, as already discussed in other relevant papers, 7,11 these effects are almost doubled those of paracetamol, 60 a common medication used for knee OA pain-relief treatment. Moreover, other medications commonly used for the treatment of knee OA have a similar effect as observed for GS, as indicated in the recent network meta-analysis of Gregori et al in which GS and celecoxib were the only long-term OA treatments associated with pain reduction [effect size (ES) = 0.29 and ES = 0.18, respectively].…”

An interpretable boosting model to predict side effects of analgesics for osteoarthritis

“…It is well known that blood pressure is closely related to cardiovascular disease, blood pressure is a secondary risk factor in that blood pressure pills may increase the risk [9, 10], the analgesics can have a direct side effect on blood pressure. For patients with abnormal blood pressure, they should be careful in using analgesics.…”