Accuracy of non-gated low-dose non-contrast chest CT with tin filtration for coronary artery calcium scoring

Liu, Ying; Chen, Xuezhi; Liu, Xianchen; Yu, Hao; Zhou, Lianjun; Gao, Xiaoling; Li, Qinglin; Su, Shujun; Wang, Lin; Zhai, Jia

doi:10.1016/j.ejro.2022.100396

Cited by 3 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While image noise was high and spatial resolution reduced, compared to CCTA, it cannot be ruled out that large coronary lesions could be visualised from our data. Similarly, the coronary calcium score could potentially be measured using ungated planning scans [39] . However, in the absence of a suitable reference standard, we did not examine these aspects.…”

Section: Discussionmentioning

confidence: 99%

Minimal dose CT for left ventricular ejection fraction and combination with chest-abdomen-pelvis CT

Kusk,

Hess,

Gerke

et al. 2024

European Journal of Radiology Open

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Minimal dose CT for left ventricular ejection fraction and combination with chest-abdomen-pelvis CT

Kusk,

Hess,

Gerke

et al. 2024

European Journal of Radiology Open

View full text Add to dashboard Cite

Exploring the interplay between epicardial fat, coronary artery calcium score, and nonalcoholic fatty liver disease through non‐ECG‐gated chest computed tomography: A cross‐sectional study

Moradi,

Abed,

Zarei

et al. 2024

Health Science Reports

View full text Add to dashboard Cite

Background and AimsThis study examines the relationships between epicardial adipose tissue (EAT), nonalcoholic fatty liver disease (NAFLD), and coronary artery calcium score (CACS) using non‐ECG‐gated CT scans. It aims to determine the effectiveness of EAT measurements and NAFLD as predictors for coronary artery disease (CAD).MethodsThis cross‐sectional study was conducted at a specialized center, focusing on individuals who underwent non‐ECG‐gated chest CT scans without contrast. We evaluated EAT thickness and density in three areas: the right atrioventricular groove, the free wall of the right ventricle, and the central area of the right anterior interventricular groove. Additionally, we measured CACS and determined the presence of NAFLD by comparing liver‐to‐spleen density ratios. Statistical analyses, including regression models, were performed using SPSS (version 26).ResultsIn this study, we enrolled 365 participants, including 203 males with an average age of 47 ± 17.93 years. EAT thickness was 6.28 ± 1.62 mm, and EAT density was −96.07 ± 12.47 Hounsfield units (HU). The mean CACS was 22.27 ± 79.01, and the mean liver density was 50.01 ± 10.76 HU. A significant positive correlation was observed between EAT thickness and CACS (r = 0.208, p < 0.001). EAT density showed a significant negative correlation with CACS (r = −0.155, p = 0.003). No correlation was found between NAFLD and CACS. Univariate logistic regression analysis identified significant predictors of increased CACS, including EAT thickness (OR: 1.803), EAT density (OR: 0.671), diabetes mellitus (DM) (OR: 5.921), and hypertension (HTN) (OR: 7.414). Multivariate analysis confirmed the significance of EAT thickness (OR: 0.682), DM (OR: 3.66), and HTN (OR: 2.79) as predictors of elevated CACS.ConclusionOur findings demonstrate that increased EAT thickness and decreased density are associated with higher CACS. Also, both DM and HTN significantly contribute to increased CACS. These results support the inclusion of EAT measurements in cardiovascular risk assessment models to enhance diagnostic accuracy.

show abstract

Prevalence and clinical implications of coronary artery calcium scoring on non-gated thoracic computed tomography: a systematic review and meta-analysis

Osborne-Grinter,

Ali,

Williams

2023

Eur Radiol

View full text Add to dashboard Cite

Objectives Coronary artery calcifications (CACs) indicate the presence of coronary artery disease. CAC can be found on thoracic computed tomography (CT) conducted for non-cardiac reasons. This systematic review and meta-analysis of non-gated thoracic CT aims to assess the clinical impact and prevalence of CAC. Methods Online databases were searched for articles assessing prevalence, demographic characteristics, accuracy and prognosis of incidental CAC on non-gated thoracic CT. Meta-analysis was performed using a random effects model. Results A total of 108 studies (113,406 patients) were included (38% female). Prevalence of CAC ranged from 2.7 to 100% (pooled prevalence 52%, 95% confidence interval [CI] 46–58%). Patients with CAC were older (pooled standardised mean difference 0.88, 95% CI 0.65–1.11, p < 0.001), and more likely to be male (pooled odds ratio [OR] 1.95, 95% CI 1.55–2.45, p < 0.001), with diabetes (pooled OR 2.63, 95% CI 1.95–3.54, p < 0.001), hypercholesterolaemia (pooled OR 2.28, 95% CI 1.33–3.93, p < 0.01) and hypertension (pooled OR 3.89, 95% CI 2.26–6.70, p < 0.001), but not higher body mass index or smoking. Non-gated CT assessment of CAC had excellent agreement with electrocardiogram-gated CT (pooled correlation coefficient 0.96, 95% CI 0.92–0.98, p < 0.001). In 51,582 patients, followed-up for 51.6 ± 27.4 months, patients with CAC had increased all cause mortality (pooled relative risk [RR] 2.13, 95% CI 1.57–2.90, p = 0.004) and major adverse cardiovascular events (pooled RR 2.91, 95% CI 2.26–3.93, p < 0.001). When CAC was present on CT, it was reported in between 18.6% and 93% of reports. Conclusion CAC is a common, but underreported, finding on non-gated CT with important prognostic implications. Clinical relevance statement Coronary artery calcium is an important prognostic indicator of cardiovascular disease. It can be assessed on non-gated thoracic CT and is a commonly underreported finding. This represents a significant population where there is a potential missed opportunity for lifestyle modification recommendations and preventative therapies. This study aims to highlight the importance of reporting incidental coronary artery calcium on non-gated thoracic CT. Key Points • Coronary artery calcification is a common finding on non-gated thoracic CT and can be reliably identified compared to gated-CT. • Coronary artery calcification on thoracic CT is associated with an increased risk of all cause mortality and major adverse cardiovascsular events. • Coronary artery calcification is frequently not reported on non-gated thoracic CT.

show abstract

Accuracy of non-gated low-dose non-contrast chest CT with tin filtration for coronary artery calcium scoring

Cited by 3 publications

References 14 publications

Minimal dose CT for left ventricular ejection fraction and combination with chest-abdomen-pelvis CT

Minimal dose CT for left ventricular ejection fraction and combination with chest-abdomen-pelvis CT

Exploring the interplay between epicardial fat, coronary artery calcium score, and nonalcoholic fatty liver disease through non‐ECG‐gated chest computed tomography: A cross‐sectional study

Prevalence and clinical implications of coronary artery calcium scoring on non-gated thoracic computed tomography: a systematic review and meta-analysis

Contact Info

Product

Resources

About