Accuracy of magnetic resonance enterography in the preoperative assessment of patients with Crohn's disease of the small bowel

Pous‐Serrano, Salvador; Frasson, Matteo; Giménez, R Palasí; Sanchez-Jordá, G; Pamíes-Guilabert, José; Ros, Margarita Llavador; Mateu, Pilar Nos; García‐Granero, Eduardo

doi:10.1111/codi.13613

Cited by 21 publications

(9 citation statements)

References 20 publications

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“…The MRE sensitivities of 79% and 87% for OR and SR, respectively, are comparable to existing literature (75-100%). 5,[14][15][16] The accuracy of different imaging modalities for the identification of specific findings such as strictures rely on several factors including the definition of strictures and reference standard used. Such definitions are variably reported in radiological studies.…”

Section: Discussionmentioning

confidence: 99%

Sensitivity of pre‐operative imaging and radiologist inter‐rater reliability in detecting lesions in Crohn's disease

Hong

Kutaiba

Parameswaran

et al. 2022

ANZ Journal of Surgery

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Section: Discussionmentioning

confidence: 99%

Sensitivity of pre‐operative imaging and radiologist inter‐rater reliability in detecting lesions in Crohn's disease

Hong

Kutaiba

Parameswaran

et al. 2022

ANZ Journal of Surgery

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“…In comparison, MR enterography (MRE) based on MR techniques has excellent capability to assess the degree of inflammation. However, the differentiation of fibrosis from inflammation in CD strictures through currently available cross-sectional imaging techniques remains challenging ( Rimola et al, 2011 ; Rimola et al, 2015 ; Pous-Serrano et al, 2017 ; Li et al, 2018 ; Wagner et al, 2018 ; Wilkens et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

A Type I Collagen-Targeted MR Imaging Probe for Staging Fibrosis in Crohn’s Disease

Lin

et al. 2021

Front. Mol. Biosci.

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Fibrostenosis is a serious complication of Crohn’s disease (CD), affecting approximately one-half of all patients. Surgical resection is the typical clinical end due to ineffective antifibrotic therapy mainly through anti-inflammatory treatment and fibrosis can be reverted only at early stages. Mover, human fibrotic disorders is known to be associated with aging process. Thus, accurate monitoring of the progression of fibrosis is crucial for CD management as well as can be benefit to aging related fibrosis. The excessive deposition of type I collagen (ColI) is the core point in major complications of fibrosis, including that in patients with CD and aging related fibrosis. Therefore, a MR imaging probe (EP-3533) targeted ColI was employed to stage bowel fibrosis in CD using a rat model and to compare its efficiency with the common MR imaging contrast medium gadopentetatedimeglumine (Gd-DTPA). The bowel fibrotic rat model was established with different degrees of bowel fibrosis, were scanned using a 3.0-T MRI scanner with a specialized animal coil. MRI sequence including T1 mapping and T1-weighed imaging were performed before and after injecting the MRI probe (EP-3533 or Gd-DTPA). The T1 relaxation time (T1 value) and change in the contrast-to-noise ratio (ΔCNR) were measured to evaluate bowel fibrosis. Masson’s trichrome staining was performed to determine the severity of fibrosis. EP-3533 offered a better longitudinal relaxivity (r1) with 67.537 L/mmol·s, which was approximately 13 times that of Gd-DTPA. The T1 value on bowel segments was reduced in the images from EP-3533 compared to that from Gd-DTPA (F = 16.478; p < 0.001). Additionally, a better correlation between ΔCNR calculated from EP-3533 imaging and bowel fibrosis (AUC = 0.846) was determined 10 min after enhanced media administration than with Gd-DTPA (AUC = 0.532). The 10th-minute ΔCNR performed using the ColI probe showed the best correlation with the severity of bowel fibrosis (r = 0.538; p = 0.021). Our results demonstrates that targeted MRI probe (EP-3533) supplies a better enhanced effect compared to Gd-DTPA and could be a promising method to evaluate the progression and monitor the therapeutic response of bowel fibrosis.

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“…The sensitivity and specificity of CTE for stricture identification are as high as 100%, respectively [37,40]. Similarly, the sensitivity and specificity of MRE for stricture identification are 100% and 96%, respectively [37,41]. Though either of these techniques may be used to diagnose intestinal strictures, MRE may be the preferred approach due to lack of exposure to ionizing radiation.…”

Section: Cross-sectional Imaging In Stricture Diagnosismentioning

confidence: 99%

Management of the Hospitalized Patient with Inflammatory and Stricturing Crohn’s Disease

Tandon

Weizman

2021

Management of Inpatient Inflammatory Bowel Disease

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Accuracy of magnetic resonance enterography in the preoperative assessment of patients with Crohn's disease of the small bowel

Abstract: Magnetic resonance enterography is a useful tool in the preoperative assessment of patients with Crohn's disease. However, a thorough intra-operative exploration of the entire small bowel is still necessary.

Cited by 21 publications

References 20 publications

Sensitivity of pre‐operative imaging and radiologist inter‐rater reliability in detecting lesions in Crohn's disease

Sensitivity of pre‐operative imaging and radiologist inter‐rater reliability in detecting lesions in Crohn's disease

A Type I Collagen-Targeted MR Imaging Probe for Staging Fibrosis in Crohn’s Disease

Management of the Hospitalized Patient with Inflammatory and Stricturing Crohn’s Disease

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