Accuracy of Helical Computed Tomography and [<sup>18</sup>F] Fluorodeoxyglucose Positron Emission Tomography for Identifying Lymph Node Mediastinal Metastases in Potentially Resectable Non–Small-Cell Lung Cancer

Pozo-Rodrı́guez, Francisco; Nicolás, J.L. Martín de; Sánchez-Nistal, María A.; Maldonado, Antonio; Barajas, S. García; Calero-García, Rosa; Pozo, Miguel A.; Martı́n-Escribano, Pedro; Martín-García, Isabel San; García-Luján, Ricardo; López-Encuentra, Ángel; Pablo, A. Arenas De

doi:10.1200/jco.2004.00.6361

Cited by 93 publications

(52 citation statements)

References 26 publications

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“…Surgical specimens, study procedures, and clinical information of patients with potentially respectable non-small-cell lung cancer were those described previously (8). A summary of relevant clinicopathologic information of the cohort of patients analyzed is provided in Table 1.…”

Section: Methodsmentioning

confidence: 99%

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Loss of the Mitochondrial Bioenergetic Capacity Underlies the Glucose Avidity of Carcinomas

et al. 2007

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The down-regulation of the catalytic subunit of the mitochondrial H + -ATP synthase (B-F1-ATPase) is a hallmark of most human carcinomas. This characteristic of the cancer cell provides a proteomic signature of cellular bioenergetics that can predict the prognosis of colon, lung, and breast cancer patients. Here we show that the in vivo tumor glucose uptake of lung carcinomas, as assessed by positron emission tomography in 110 patients using 2-deoxy-2-[18 F]fluoro-D-glucose as probe, inversely correlates with the bioenergetic signature determined by immunohistochemical analysis in tumor surgical specimens. Further, we show that inhibition of the activity of oxidative phosphorylation by incubation of cancer cells with oligomycin triggers a rapid increase in their rates of aerobic glycolysis. Moreover, we show that the cellular expression level of the B-F1-ATPase protein of mitochondrial oxidative phosphorylation inversely correlates (P < 0.001) with the rates of aerobic glycolysis in cancer cells. The results highlight the relevance of the alteration of the bioenergetic function of mitochondria for glucose capture and consumption by aerobic glycolysis in carcinomas. [Cancer Res 2007;67(19):9013-7]

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Section: Methodsmentioning

confidence: 99%

“…PET examinations were done in 6-h-fasted patients using an ECAT EXACT 47 (Siemens-CTI) camera with whole-body attenuation (8). Patients entering the PET study had blood glucose concentrations <7 mmol/L.…”

Section: Methodsmentioning

confidence: 99%

Loss of the Mitochondrial Bioenergetic Capacity Underlies the Glucose Avidity of Carcinomas

et al. 2007

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“…This ratio is reported as 16%-55% in the literature (9,11). In another study, it has been determined that not only the active inflammation, but also the healed or inactive pulmonary diseases (antecedent tuberculosis, silicosis, anthracosis) may potentially result in increased FDG capture in hilar or mediastinal lymph nodes (12). False positivity was determined in 34.6% of lymph nodes detected in PET/CT imaging in our study group.…”

Section: Discussionmentioning

confidence: 76%

The evaluation of hypermetabolic mediastinal–hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA

KANDEMİR¹,

ŞENTÜRK²,

Özdemir³

et al. 2015

Turk J Med Sci

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Background/aim: We aimed to define the optimal SUVmax cut-off value in determination of mediastinal-hilar lymph node metastasis, by comparing positive PET/CT results with the results of endobronchial ultrasound guided transbronchial needle aspiration biopsy (EBUS-TBNA).Materials and methods: Thirty-one patients with malignancy whose PET/CT imaging revealed a hypermetabolic mediastinal and/ or hilar lymph node and who had undergone EBUS-TBNA were evaluated retrospectively. Histopathology was regarded as the gold standard. The diagnostic role of PET/CT in mediastinal/hilar lymph node metastasis was investigated and compared with the results of contrast-enhanced CT.Results: When a SUVmax value of 2.5 was used, the sensitivity, positive predictive value (PPV), and diagnostic accuracy of the PET/CT were 100%, 65.4%, and 65.4% respectively. In the ROC analysis, the SUVmax cut-off value with the highest diagnostic accuracy (75%) was calculated as 6.3, and when this value was considered, the sensitivity, specificity, PPV, negative predictive value, and diagnostic accuracy of the PET/CT were determined as 70.6%, 83.3%, 88.9%, 60%, and 75% respectively (AUC: 0.779). The sensitivity, PPV, and diagnostic accuracy of the thorax CT were calculated as 91.1%, 72%, and 71.1%, respectively. Conclusion:When determining mediastinal-hilar lymph node metastasis via PET/CT, although a SUVmax cut-off value of 6.3 increases specificity and diagnostic accuracy, we think that a SUVmax cut-off value of 2.5 and above give more optimal results in routine practice.

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“…Some of the studies that established very high sensitivities and negative predictive values of pet-ct in the mediastinum involved patients whose pet imaging was performed within 72 hours of surgery 25 . Mohammed et al 27 showed that clinical progression occurred in 21% of patients after 16 weeks' delay in surgery, and initially higher T and N stages were associated with more rapid progression.…”

Section: Discussionmentioning

confidence: 99%

Using pet-ct to Reduce Futile Thoracotomy Rates in Non-Small-Cell Lung Cancer: A Population-Based Review

et al. 2014

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Accuracy of Helical Computed Tomography and [¹⁸F] Fluorodeoxyglucose Positron Emission Tomography for Identifying Lymph Node Mediastinal Metastases in Potentially Resectable Non–Small-Cell Lung Cancer

Abstract: hCT and PET perform similarly in the mediastinal staging of NSCLC, both tests are conditionally dependent and provide complementary information, and their diagnostic value mainly resides on the negative results.

Cited by 93 publications

References 26 publications

Loss of the Mitochondrial Bioenergetic Capacity Underlies the Glucose Avidity of Carcinomas

Loss of the Mitochondrial Bioenergetic Capacity Underlies the Glucose Avidity of Carcinomas

The evaluation of hypermetabolic mediastinal–hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA

Using pet-ct to Reduce Futile Thoracotomy Rates in Non-Small-Cell Lung Cancer: A Population-Based Review

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Accuracy of Helical Computed Tomography and [18F] Fluorodeoxyglucose Positron Emission Tomography for Identifying Lymph Node Mediastinal Metastases in Potentially Resectable Non–Small-Cell Lung Cancer

Abstract: hCT and PET perform similarly in the mediastinal staging of NSCLC, both tests are conditionally dependent and provide complementary information, and their diagnostic value mainly resides on the negative results.

Cited by 93 publications

References 26 publications

Loss of the Mitochondrial Bioenergetic Capacity Underlies the Glucose Avidity of Carcinomas

Loss of the Mitochondrial Bioenergetic Capacity Underlies the Glucose Avidity of Carcinomas

The evaluation of hypermetabolic mediastinal–hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA

Using pet-ct to Reduce Futile Thoracotomy Rates in Non-Small-Cell Lung Cancer: A Population-Based Review

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Accuracy of Helical Computed Tomography and [¹⁸F] Fluorodeoxyglucose Positron Emission Tomography for Identifying Lymph Node Mediastinal Metastases in Potentially Resectable Non–Small-Cell Lung Cancer