“…In the detection of residual disease after NAC, a meta-analysis reported a pooled sensitivity with CEM of 80.7% (95% CI 65.5–90.2%) and a pooled specificity of 94.0% (95% CI = 78.3–98.6%) [ 18 ]. The literature investigating the role of CEM in the assessment of residual breast cancer following NAC continues to increase [ 19 , 20 , 21 , 22 , 23 ]; to the best of our knowledge, this is the first study that aims to evaluate the specific contribution of calcifications in this context. The implications of residual calcifications after NAC are still debated; since some calcifications may represent treated cancer with calcified or necrotic tissue and sloughed cells, their persistence in the tumor bed evaluated exclusively with mammography has not correlated with residual neoplasia [ 24 , 25 , 26 , 27 , 28 , 29 , 30 ].…”