Accuracy of Collateral Source Reports in Very Mild to Mild Dementia of the Alzheimer Type

Cacchione, Pamela Z.; Powlishta, Kimberly K.; Grant, Elizabeth; Buckles, Virginia; Morris, John C.

doi:10.1046/j.1365-2389.2003.51263.x

Cited by 76 publications

(70 citation statements)

References 26 publications

(51 reference statements)

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“…In previous work on this topic, rater accuracy, as indexed by correlations with performance-based cognitive measures, was found to be highest in respondents who were married to, living with or in frequent contact with the patient [15] . However, a recent study found cross-cultural differences in the effect of respondent-patient relationship [16] .…”

Section: Discussionmentioning

confidence: 87%

French-English Cross-Linguistic Comparison and Diagnostic Impact of the AD-8 Dementia Screening Questionnaire in a Geriatric Assessment Clinic

Koski

Xie

Konsztowicz

et al. 2010

Dement Geriatr Cogn Disord

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The AD-8 dementia screening questionnaire is a novel tool that allows clinicians to assess changes in cognitive function. This study examined psychometric properties of the test in French-speaking and English-speaking patients, and its impact on diagnostic practice in the geriatric assessment clinics of a university health centre. Data were extracted from the clinical database for all new patients screened for cognitive impairment 15 months before (historic control group) and 15 months after the introduction of the test (AD-8 group and concurrent control group). Analysis of differential item functioning revealed formal equivalence of the French- and English-language items, supporting the validity of the French version. Respondent type significantly influenced the total score on the AD-8. Concurrent validity with other cognitive screening tests was moderately high. Finally, among patients who did not present with pre-existing dementia, a higher proportion of dementia diagnoses was made in those administered the AD-8 relative to the concurrent control group. Implications for clinical use of the AD-8 are discussed.

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Section: Discussionmentioning

confidence: 87%

French-English Cross-Linguistic Comparison and Diagnostic Impact of the AD-8 Dementia Screening Questionnaire in a Geriatric Assessment Clinic

Koski

Xie

Konsztowicz

et al. 2010

Dement Geriatr Cogn Disord

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“…The lower rates in these studies likely result from several factors. First, in contrast to clinic-based samples [47] , persons in community-based studies are often not recognized by family members [48] or community physicians [49] as having cognitive difficulties. Second, in longitudinal, community-based studies, the diagnosis of AD is often made at a time when cognitive impairment is mild and the presence of dementia unclear.…”

Section: Discussionmentioning

confidence: 99%

Decision Rules Guiding the Clinical Diagnosis of Alzheimer’s Disease in Two Community-Based Cohort Studies Compared to Standard Practice in a Clinic-Based Cohort Study

Schneider²,

et al. 2006

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We developed prediction rules to guide the clinical diagnosis of Alzheimer’s disease (AD) in two community-based cohort studies (the Religious Orders Study and the Rush Memory and Aging Project). The rules were implemented without informant interviews, neuroimaging, blood work or routine case conferencing. Autopsies were performed at death and the pathologic diagnosis of AD made with a modified version of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) criteria. We compared the positive predictive value of the clinical diagnosis in the two community-based studies to the positive predictive value of the clinical diagnosis of AD made by standard clinical practice in a clinic-based cohort study using AD pathology as the gold standard. Of 306 clinic cases with probable AD, 286 (93.5%) met CERAD neuropathologic criteria for AD; the results were comparable for those with possible AD (51 of 54, 94.4%). Of 141 study subjects with probable AD, 130 (92.2%) met CERAD neuropathologic criteria for AD; the results were lower but acceptable for those with possible AD (26 of 37, 70.3%). The results were similar in secondary analyses using alternate neuropathologic criteria for AD. The clinical diagnosis of AD can be made in community-based studies without the use of informant interviews, neuroimaging, blood work or routine case conferencing. This approach holds promise for reducing the operational costs of epidemiologic studies of aging and AD.

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“…The quality of these data, however, depends on the insightfulness and accuracy of the informant. It remains possible that informants were not aware of extant nonmemory defi cits, although collateral sources tend to be fairly accurate when describing the cognitive impairments in patients with even very early dementia [32] .…”

Section: Discussionmentioning

confidence: 99%

Multiple Cognitive Deficits in Amnestic Mild Cognitive Impairment

Kramer

Nelson

Johnson

et al. 2006

Dement Geriatr Cogn Disord

127

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Objective: To determine if more widespread cognitive deficits are present in a narrowly defined group of patients with the amnestic form of mild cognitive impairment (MCI). Methods: From a larger sample of patients clinically diagnosed as meeting the criteria of Petersen et al. for amnestic MCI, we selected 22 subjects who had Clinical Dementia Rating scores of zero on all domains besides memory and orientation. These MCI subjects with presumably isolated memory impairments were compared to 35 age-matched normal controls and 33 very mild Alzheimer’s disease (AD) patients on a battery of neuropsychological tests. Result: In addition to the expected deficits in episodic memory, the amnestic MCI group performed less well than the controls but better than the AD group on design fluency, category fluency, a set shifting task and the Stroop interference condition. Over half the amnestic MCI group (vs. none of the normal controls) scored at least 1 standard deviation below control means on 4 or more of the nonmemory cognitive tasks. Conclusions: Isolated memory impairment may be fairly uncommon in clinically diagnosed amnestic MCI patients, even when the criteria for amnestic MCI are fairly narrow. Additional cognitive impairments are likely to include fluency and executive functioning. These more diffuse deficits argue for comprehensive cognitive assessments, even when the patient and family are reporting only memory decline, and are consistent with the increase in attention paid to the heterogeneity of MCI.

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Accuracy of Collateral Source Reports in Very Mild to Mild Dementia of the Alzheimer Type

Abstract: Collateral sources are accurate in reporting the cognitive capabilities of individuals with DAT, even in the very mild stage of dementia.

Cited by 76 publications

References 26 publications

French-English Cross-Linguistic Comparison and Diagnostic Impact of the AD-8 Dementia Screening Questionnaire in a Geriatric Assessment Clinic

French-English Cross-Linguistic Comparison and Diagnostic Impact of the AD-8 Dementia Screening Questionnaire in a Geriatric Assessment Clinic

Decision Rules Guiding the Clinical Diagnosis of Alzheimer’s Disease in Two Community-Based Cohort Studies Compared to Standard Practice in a Clinic-Based Cohort Study

Multiple Cognitive Deficits in Amnestic Mild Cognitive Impairment

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