Accuracy of a Novel Non-Invasive technology based EZSCAN system for the diagnosis of diabetes mellitus in Chinese

Sheng, Chang‐Sheng; Zeng, Wei-Fang; Huang, Qi‐Fang; Deslypère, J.P.; Li, Yan; Wang, Ji‐Guang

doi:10.1186/1758-5996-3-36

Cited by 27 publications

(38 citation statements)

References 15 publications

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“…Therefore, it is necessary to monitor disease spectrum changes, and prevent and detect diabetes in the early stage. The results of this study revealed that blood uric acid levels in subjects in the high-risk group were higher than that in the low-risk group and normal group, which was consistent with previous research results [10,16]. From the results of the study, we can observe that even in a high-risk population, the pilots' BMI and blood uric acid values were lower than in the general population.…”

Section: Discussionsupporting

confidence: 81%

“…Ramachandran et al [5] performed EZSCAN and glucose test on 212 subjects and found that when the EZSCAN cut-off point was 50%, the diagnostic sensitivity and specificity of diabetes were 75% and 54%, respectively, and sensitivity was higher than in fasting plasma glucose (FPG, 29%). Sheng et al [10] performed EZSCAN tests on 195 subjects. They also found that conductivity in the diabetic group was significantly lower than in the non-diabetic group.…”

Section: Discussionmentioning

confidence: 99%

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Badanie zastosowania techniki EZSCAN wśród pilotów i w populacji ogólnej

Li¹,

Wang²,

Jiang³

et al. 2018

Endokrynologia Polska

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Introduction: This study aims to evaluate EZSCAN detection in pilots and in the general population, and to determine the significance of EZSCAN detection in the identification of pilots' health. Material and methods: A total of 87 cases of non-diabetic Air Force pilots (pilot group) and 49 cases from the general population without diabetes were collected. These two groups of subjects underwent EZSCAN detection, as well as the detection of blood glucose, lipid, and uric acid levels. Results: Subjects in the pilot group had the highest detection rate of no risk and the lowest detection rate of high risk, while the general population had the highest detection rate of high risk, followed by low risk. The difference in diabetic risk between these two groups was statistically significant (P < 0.01). Various indicators were compared according to different risk levels. In the no risk group, age, BMI, and the triglyceride of pilots were lower than in the general population, and the difference was statistically significant (P < 0.05). In high risk group, BMI and blood uric acid of pilots were lower than in the general population, and the difference was statistically significant (P < 0.05). Conclusions: BMI and blood uric acid are positively correlated with diabetic risk. The EZSCAN detection system can be used for assessment of pilots' diabetic risk and has certain significance in pilots' health identification.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Badanie zastosowania techniki EZSCAN wśród pilotów i w populacji ogólnej

Li¹,

Wang²,

Jiang³

et al. 2018

Endokrynologia Polska

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“…15 Strengths of our study include good measurement properties for the instrumentation used. [8][9][10][11][12]17,19,21,22 We also allowed for a thermal wash-out period 15 between testing and randomized the insole testing sequence. We assessed for gait and balance changes under single and dual task conditions.…”

Section: Discussionmentioning

confidence: 99%

A Novel Shear Reduction Insole Effect on the Thermal Response to Walking Stress, Balance, and Gait

Wrobel

Peethambaran

et al. 2014

J Diabetes Sci Technol

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Reducing shear or side-to-side stresses on the plantar surfaces of feet in patients with diabetes is of particular interest lately. Conflicting clinical trial data of custom pressure-reducing footwear suggest that other offloading or footwear approaches may be necessary. 1,2 Gait lab studies suggest shear stresses are in a different location and magnitude versus age-matched controls. 3 Shear stresses in the foot also demonstrate a large association with thermal changes in response to walking in patients with diabetes and peripheral neuropathy. 4 Currently, there are no commercially available products to detect shear inside the shoe. However, relative temperature changes using thermometry may represent antecedent inflammatory changes from shear and pressure occurring prior to clinical expression of foot ulceration at the skin level. Purposeful "cooling" of the foot in clinical trials resulted in effect sizes of 4-to 10-fold reduction in reulceration. 5-7 Autonomic neuropathy can also affect thermoregulation of foot temperature and may be a more sensitive measure 8 for predicting foot ulcer. 9 In this study we measured sudomotor function for small fiber autonomic neuropathy. 10-12 Shear-reducing insoles that permit side-to-side motion in the device to reduce shear at the skin and deeper tissue level may make patients feel unsteady and less confident with walking. Therefore, in this study, we measured gait and balance changes under single and dual task conditions to explore for gait adaptations. In addition, these measurements may 546528D STXXX10.

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“…In verschiedenen klinischen Studien war eine gute Korrelation der EZSCAN™-Risikostratifizierung mit Glukose-, Insulin-und Proinsulinwerten, die mit einem oGTT gemessen werden, nachweisbar [38,41]. Außerdem ergaben sich unterschiedliche Scanverläufe bei Patienten, die hyperglykämisch und insulinresistent waren, sich aber durch den Grad des β-Zell-Versagens voneinander unterschieden.…”

Section: -H-glukosemessungunclassified

Diabetesscreening und -vorsorge

Schwarz

2015

Internist

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A valid and efficient screening for individual diabetes risk is a highly welcomed tool in primary care and specialist medical practice. It is needed to detect early stages of diabetes risk and prediabetes and to start interventions that have the aim to prevent diabetes and also other chronic diseases from developing. The oral glucose tolerance test is the gold standard, but it is difficult to perform in an evidence-based manner in primary care. Furthermore, measuring fasting and 2-h postprandial glucose values detects only late stages of the pathophysiological development of type 2 diabetes. Interestingly, the 1-h glucose value is highly predictive of future diabetes risk, but is rarely used in primary care. Therefore, risk scores are commonly used to evaluate diabetes risk, but unfortunately, they generally do not mirror the relevance of increased risk due to the person's own lifestyle. Measuring waist circumference is another possibility, because the waist is directly associated with the amount of visceral fat, which again directly correlates with the pathophysiology of diabetes development. A further possibility is the EZSCAN™ technology. The EZSCAN™ is based on reverse iontophoresis, a new technology to detect very early forms of peripheral neuropathies, which are commonly associated with early diabetes risk stages. It is important to perform diabetes screening in a targeted manner, in both medical and paramedical environments, and it is mandatory to add targeted interventions, based on the screening evaluated diabetes risk.

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Accuracy of a Novel Non-Invasive technology based EZSCAN system for the diagnosis of diabetes mellitus in Chinese

Cited by 27 publications

References 15 publications

Badanie zastosowania techniki EZSCAN wśród pilotów i w populacji ogólnej

Badanie zastosowania techniki EZSCAN wśród pilotów i w populacji ogólnej

A Novel Shear Reduction Insole Effect on the Thermal Response to Walking Stress, Balance, and Gait

Diabetesscreening und -vorsorge

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