2000
DOI: 10.1001/archderm.136.4.497
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Accuracy, Concordance, and Reproducibility of Histologic Diagnosis in Cutaneous T-Cell Lymphoma<subtitle>An EORTC Cutaneous Lymphoma Project Group Study</subtitle>

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Cited by 58 publications
(32 citation statements)
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“…34,35 This emphasizes the need for clinicopathologic correlation when interpreting the results of clonality studies. While several authors have suggested evolving histologic criteria for the diagnosis of cutaneous T-cell lymphoma over the past several years, [36][37][38][39] ultimately, clinicopathologic correlation is essential when differentiating MF from its histologic mimickers.…”
Section: Resultsmentioning
confidence: 99%
“…34,35 This emphasizes the need for clinicopathologic correlation when interpreting the results of clonality studies. While several authors have suggested evolving histologic criteria for the diagnosis of cutaneous T-cell lymphoma over the past several years, [36][37][38][39] ultimately, clinicopathologic correlation is essential when differentiating MF from its histologic mimickers.…”
Section: Resultsmentioning
confidence: 99%
“…4,[6][7][8][9][10][11] The histopathologic features of early MF vary from person to person, over time, and even between multiple sites in a single patient. 12,13 In addition, Figure 1.…”
Section: Commentmentioning
confidence: 99%
“…4,14 These difficulties are highlighted by reported false-negative and false-positive rates as high as 40%, 15 in addition to low concordance and reproducibility rates. 4,[8][9][10] Because of these diagnostic challenges in early MF, during the past decades, several authors have attempted to identify the most-reliable diagnostic criteria for distinguishing MF from benign dermatoses. 4,5,7,[10][11][12][13][14]16,17 Characteristic histopathologic features of early MF include the presence of enlarged epidermal lymphocytes with cerebriform nuclei within the epidermis and minimal associated spongiosis (epidermotropism), larger lymphocytes in the epidermis than in the dermis, lymphocytes with perinuclear clearing (halo), and a linear arrangement of basilar epidermal lymphocytes along the dermal-epidermal junction (tagging) (Figure 2, B through D).…”
Section: Commentmentioning
confidence: 99%
“…The two entities represent the same disease presenting in cutaneous plaque or infiltrating form (MF) and disseminated erythroderma form (SSx). Prolonged monitoring may be needed to distinguish these entities from other hyperkeratotic and reactive skin lesions, and diagnostic accuracy in early stages may be as low as 40% [46]. Repeated skin biopsies for cerebriform T-cell infiltration and Pautrier microabscesses and gene rearrangement studies may be necessary [47••].…”
Section: Cutaneous Group Mycosis Fungoides and Sezary Syndromementioning
confidence: 99%