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Cited by 37 publications
(27 citation statements)
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References 61 publications
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“…This stronger IONP accumulation by microglial cells is consistent with literature data for other types of IONPs (Jenkins et al, 2013;Pinkernelle et al, 2012). Different types of endocytotic pathways involved in IONP uptake are unlikely to explain the observed differences in IONP accumulation between the three types of neural cells investigated as in serum-containing media clathrinmediated endocytosis and macropinocytosis have been reported to mediate IONP uptake into both cultured microglial cells and astrocytes (Geppert et al, 2013;Luther et al, 2013), while neurons appear to take up IONPs predominantly by clathrinmediated endocytosis (Petters & Dringen, 2015). However, as microglia are the ''phagocytotic cells'' in the brain and as microglial cells, but not astrocytes and neurons, have the prominent function to incorporate and digest cell debris from their environment (Eyo & Dailey, 2013;Nayak et al, 2014), microglial cells are likely to be equipped with a strong endocytotic transport capacity, which could explain the higher efficiency of microglial cells to accumulate iron from low concentrations of IONPs.…”
Section: Discussionsupporting
confidence: 90%
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“…This stronger IONP accumulation by microglial cells is consistent with literature data for other types of IONPs (Jenkins et al, 2013;Pinkernelle et al, 2012). Different types of endocytotic pathways involved in IONP uptake are unlikely to explain the observed differences in IONP accumulation between the three types of neural cells investigated as in serum-containing media clathrinmediated endocytosis and macropinocytosis have been reported to mediate IONP uptake into both cultured microglial cells and astrocytes (Geppert et al, 2013;Luther et al, 2013), while neurons appear to take up IONPs predominantly by clathrinmediated endocytosis (Petters & Dringen, 2015). However, as microglia are the ''phagocytotic cells'' in the brain and as microglial cells, but not astrocytes and neurons, have the prominent function to incorporate and digest cell debris from their environment (Eyo & Dailey, 2013;Nayak et al, 2014), microglial cells are likely to be equipped with a strong endocytotic transport capacity, which could explain the higher efficiency of microglial cells to accumulate iron from low concentrations of IONPs.…”
Section: Discussionsupporting
confidence: 90%
“…The specific iron contents determined were in the range of values previously reported for these cultures in serum-containing media (Geppert et al, 2011(Geppert et al, , 2013Petters & Dringen, 2015). Comparison of microglial cultures with astrocytes and neurons revealed that microglial cells accumulated IONPs more efficiently when the different types of cultures were treated with low concentrations of 0.1 mM or 0.3 mM IONPs as demonstrated by the 2 -to 5-fold higher specific cellular iron contents in microglial cells.…”
Section: Discussionsupporting
confidence: 72%
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“…Despite its high utility, it should be noted that investigations into the potential adverse effects of this technology on neuron biology rely almost exclusively on relatively simple histological readouts such as cell adherence, phenotypic evaluation, live/dead staining, viable cell counts using flow cytometry, mitochondrial toxicity assays and lactate dehydrogenase (LDH) activity [11]. However, a crucial knowledge gap currently exists in relation to magnetofection technology for neuronal applications, namely, whether this bioengineering approach alters neuronal excitability.…”
Section: Ministry Of Higher Education and Scientific Researchmentioning
confidence: 99%