Accumulation of FoxP3‐expressing CD4<sup>+</sup>CD25<sup>+</sup>T cells with distinct chemokine receptors in synovial fluid of patients with active rheumatoid arthritis

Jiao, Zhijun; Wang, W; Jia, R; Li, J; You, Hua; Chen, L; Wang, Y

doi:10.1080/03009740701482800

Cited by 106 publications

(77 citation statements)

References 31 publications

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“…The mean (± SD) percentages of CD4+CD25 bright as well as the total CD4+ CD25+ T cells are in line with the published "normal" values [9,16,17]. CD4+CD25+ T cells have been investigated in several autoimmune diseases, presenting conflicting results in most cases [14][15][16][17][18][19][20][21][22]. These discrepancies may be attributed to the differences in the selection of patients (active or inactive diseases) or probably due to technical difficulties in CD4+ CD25+ T cells phenotypic characterization.…”

Section: Fig (2) Percentages Of Cd4+ Cd25supporting

confidence: 85%

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Quantification of CD4' CD25' Regulatory T Cells in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis

Al-Shukaili¹,

Alkaabi²,

Al-Gafri³

et al. 2009

TOAUTOJ

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Recent animal studies have shown that regulatory T cells play a crucial role in the suppression of the immune response and that depletion of this subset of T cells might lead to development of autoimmune diseases. The aim of this work was to quantify regulatory T cells (CD4+ CD25+) in the peripheral blood of Omani patients with Systemic Lupus Erythematosus (SLE) and Rheumatoid arthritis (RA) and correlate these findings with the disease activity of the patients. Thirty patients with SLE, 30 patients with RA and 25 healthy volunteers were enrolled in this study. Patients were divided into highly active or low active groups, depending on the disease activity. Flow cytometer was used to quantify CD4+ CD25+ T cells in the peripheral blood mononuclear cells (PBMC). We found that both highly active SLE (0.242 ± 0.3) and RA (0.56 ± 0.29) patients had significantly (p<0.001) lower levels of CD4+CD25 bright T cells than did normal controls (1.74 ± 0.47%) or patients with low disease activity (SLE=1.54 ± 0.33, RA=1.829 ± 0.76). The decreased number of CD4+CD25 bright T cells during disease activity was restored in remitting phase of SLE patients. This data provides further evidence supporting the hypothesis of defect of regulatory T cells in SLE and RA patients; which may have an important implication in the context of the control of the inflammation and development of autoimmunity.

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Section: Fig (2) Percentages Of Cd4+ Cd25supporting

confidence: 85%

“…However, Minami et al reported that the percentage of CD4+CD25+ T cells was higher in RA patients than controls, but it was not statistically significant [19]. Other reports showed increased number of these cells in RA synovial fluid but not in peripheral blood [20][21][22].…”

Section: Introductionmentioning

confidence: 95%

Quantification of CD4' CD25' Regulatory T Cells in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis

Al-Shukaili¹,

Alkaabi²,

Al-Gafri³

et al. 2009

TOAUTOJ

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“…Similarly, the absence of Treg cells in K/BxN scurfy mice is associated with faster onset and greater severity of arthritis (16). The proportion of Treg cells in RA patients is increased in the synovium but unchanged in the peripheral blood, when compared to that in healthy individuals and patients with other joint diseases (17,18). Importantly, the Treg cell phenotype and suppressive activity of Treg cells are altered in RA.…”

mentioning

confidence: 99%

Interleukin‐6 Receptor Blockade Enhances CD39+ Regulatory T Cell Development in Rheumatoid Arthritis and in Experimental Arthritis

Thiolat

Semerano

Pers

et al. 2014

Arthritis & Rheumatology

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“…This hypothesis seems to be further supported by investigations of the correlation between the percentage of Treg cells in PB and disease duration, which have confirmed higher numbers of circulating Treg cells in patients with long-standing disease [35,39]. Moreover, in established disease, where proinflammatory cytokines, including TNFα, are present at high levels in PB and target organs, FoxP3 expression within the CD4 + CD25 + cell population seems to be reduced, giving rise to the hypothesis that proinflammatory molecules play a role in inducing an abnormal Treg cell phenotype [37,40].…”

Section: The Paradox Of Treg Cell Expansion In Ra Patientsmentioning

confidence: 73%

Role of regulatory T cells in rheumatoid arthritis: facts and hypothesis

Alunno

Bartoloni

Nocentini

et al. 2010

Autoimmun Highlights

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Regulatory T cells (Treg) are a CD4 + lymphocyte subset involved in self-tolerance and autoimmunity prevention. There is evidence for a phenotypic and/or functional impairment of this cell subset during the natural history of several chronic autoimmune/inflammatory diseases, including rheumatoid arthritis (RA). Although the intracellular transcription factor FoxP3 is thought to be the master regulator of Treg cell function, a number of other molecules expressed on the cell surface have been proposed for the identification of Treg cells. This is important in order to favour their possible selective isolation and in the development of new therapeutic strategies. In the present paper, available data on phenotypic and functional characterization of Treg cells in both peripheral blood and synovial fluid from RA patients are reviewed and their possible pathogenic role in triggering and perpetuating rheumatoid joint inflammation is discussed.

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Accumulation of FoxP3‐expressing CD4⁺CD25⁺T cells with distinct chemokine receptors in synovial fluid of patients with active rheumatoid arthritis

Abstract: There is an accumulation of FoxP3-expressing regulatory T cells in RA SF, and such recruitment may be dependent on the distinct chemokine receptors expressed on regulatory T cells.

Cited by 106 publications

References 31 publications

Quantification of CD4' CD25' Regulatory T Cells in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis

Quantification of CD4' CD25' Regulatory T Cells in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis

Interleukin‐6 Receptor Blockade Enhances CD39+ Regulatory T Cell Development in Rheumatoid Arthritis and in Experimental Arthritis

Role of regulatory T cells in rheumatoid arthritis: facts and hypothesis

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Accumulation of FoxP3‐expressing CD4+CD25+T cells with distinct chemokine receptors in synovial fluid of patients with active rheumatoid arthritis

Abstract: There is an accumulation of FoxP3-expressing regulatory T cells in RA SF, and such recruitment may be dependent on the distinct chemokine receptors expressed on regulatory T cells.

Cited by 106 publications

References 31 publications

Quantification of CD4' CD25' Regulatory T Cells in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis

Quantification of CD4' CD25' Regulatory T Cells in Peripheral Blood of Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis

Interleukin‐6 Receptor Blockade Enhances CD39+ Regulatory T Cell Development in Rheumatoid Arthritis and in Experimental Arthritis

Role of regulatory T cells in rheumatoid arthritis: facts and hypothesis

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Accumulation of FoxP3‐expressing CD4⁺CD25⁺T cells with distinct chemokine receptors in synovial fluid of patients with active rheumatoid arthritis