Accumulation of Di-2-Ethylhexyl Phthalate (DEHP) in Whole Blood, Platelet Concentrates, and Platelet-Poor Plasma. 1. Effect of DEHP on Platelet Survival and Function

Valeri, C. R.; Contreras, T. J.; Feingold, H.; Sheibley, R. H.; Jaeger, R. J.

doi:10.2307/3428036

Cited by 9 publications

(6 citation statements)

References 9 publications

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“…As is usually the case with any technological advance, the development of flexible plastic bags, multiple blood pack systems, and plastic tubing for medical use has brought with it great benefits along with some risk. It is well established that DEHP leaches out of these bags and other medical devices into blood components, that the concentration increases with storage, and that DEHP is converted to MEHP, a more toxic metabolite (1)(2)(3)(4)(5)(6).…”

Section: Discussionmentioning

confidence: 99%

“…The development of flexible plastic bags and multiple pack systems has revolutionized blood banking, permitting the rapid and easy preparation of blood components for therapeutic use. However, for some time it has been known that the plasticizer di(2-ethylhexyl) phthalate (DEHP), which is added to poly(vinyl chloride) (PVC) plastics to increase flexibility, can leach from the plastic during exposure to blood and blood components (1)(2)(3)(4)(5)(6). PVC plastic is used in a great variety of medical devices, such as tubing for whole blood collection, bags for collection and storage of red cells, platelet concentrates (PC), or plasma, hemodialysis setups, tubing for intravenous injections, cytapheresis, plasma exchange and plasmapheresis.…”

Section: Introductionmentioning

confidence: 99%

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Distribution of di(2-ethylhexyl) phthalate and products in blood and blood components.

Rock¹,

Labow²,

Tocchi³

1986

Environ Health Perspect

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In order to impart flexibility, plastic medical devices incorporate liquid plasticizers into their structure. Data from several laboratories, including ours, have shown that these compounds leach from blood bags and tubing during collection of blood, storage of various blood components and during kidney dialysis and cell and plasma apheresis procedures. After the plasticizer di(2-ethylhexyl) phthalate leaches from poly(vinyl chloride) blood packs, it is converted by a plasma enzyme to a more toxic metabolite, mono(2-ethylhexyl) phthalate. Blood fractionation products from outdated plasma contain mono(2-ethylhexyl) phthalate, the highest level being found in normal serum albumin. Recently, we have reported that di(2-ethylhexyl) phthalate actually binds to the red blood cell membrane and reduces its osmotic fragility. Current methods of red cells storage, which permit utilization up to 35 days after collection, are not possible without this membrane stabilization. Platelets are now stored for 5 days in the Fenwal PL 732 polyolefin bag. Although stated to be essentially free of liquid plasticizers, a significant level of leaching from this bag into the extracts of stored platelet concentrates was observed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distribution of di(2-ethylhexyl) phthalate and products in blood and blood components.

Rock¹,

Labow²,

Tocchi³

1986

Environ Health Perspect

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“…Even if an effect of drastically reducing DEHP concentration in concentrates was to be observed, it would have been largely masked by the effect of increased gas exchange. Valeri [12] in 1973 shows that the accumulation of DEHP in platelet concentrates has no benefit on platelet viability.…”

Section: Pc Component Quality and Process Parametersmentioning

confidence: 99%

Recommendations for in vitro evaluation of blood components collected, prepared and stored in non‐DEHP medical devices

Klei

Bégué²,

Lotens³

et al. 2022

Vox Sanguinis

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Background and Objectives: DEHP, di(2-ethylhexyl) phthalate, is the most common member of the class of ortho-phthalates, which are used as plasticizers. The Medical Device Regulation has restricted the use of phthalates in medical devices. Also DEHP has been added to the Annex XIV of REACH, "Registration, Evaluation, Authorisation and Restriction of Chemicals" due to its endocrine disrupting properties to the environment. As such, the sunset date for commercialisation of DEHP-containing blood bags is May 27 th 2025. There are major concerns in meeting this deadline as these systems have not yet been fully validated and/or CE-marked. Also, since DEHP is known to affect red cell quality during storage, it is imperative to transit to non-DEHP without affecting blood product quality. Here, EBA members aim to establish common grounds on the evaluation and assessment of blood components collected, prepared and stored in non-DEHP devices.

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“…RUBIN (1972) stated that while the rate of extraction by blood is 0.2.5 mg/l00 ml/ day, no detectable extraction was found with 0.9 percent saline, five percent dextrose, or five percent protein hydrolysates. VALERI et al (1973) gave a figure of 0.32 to 0.5 mg/450 ml/ day over a 33-day period of storage at 4 DC. The agreement with JAEGER and RUBIN is good, since the increase in surface area in contact with the blood is presumably less in proportion to the volume.…”

Section: Plastics Blood Storage and Other Medical Usesmentioning

confidence: 99%

Phthalate esters: Occurrence and biological effects

Peakall

1975

Residue Reviews

191

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Accumulation of Di-2-Ethylhexyl Phthalate (DEHP) in Whole Blood, Platelet Concentrates, and Platelet-Poor Plasma. 1. Effect of DEHP on Platelet Survival and Function

Cited by 9 publications

References 9 publications

Distribution of di(2-ethylhexyl) phthalate and products in blood and blood components.

Distribution of di(2-ethylhexyl) phthalate and products in blood and blood components.

Recommendations for in vitro evaluation of blood components collected, prepared and stored in non‐DEHP medical devices

Phthalate esters: Occurrence and biological effects

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