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Cited by 40 publications
(6 citation statements)
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References 28 publications
(29 reference statements)
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“…It is well established that DEHP leaches out of these bags and other medical devices into blood components, that the concentration increases with storage, and that DEHP is converted to MEHP, a more toxic metabolite (1)(2)(3)(4)(5)(6).…”
Section: A Conclusionmentioning
confidence: 99%
See 1 more Smart Citation
“…It is well established that DEHP leaches out of these bags and other medical devices into blood components, that the concentration increases with storage, and that DEHP is converted to MEHP, a more toxic metabolite (1)(2)(3)(4)(5)(6).…”
Section: A Conclusionmentioning
confidence: 99%
“…However, for some time it has been known that the plasticizer di(2-ethylhexyl) phthalate (DEHP), which is added to poly(vinyl chloride) (PVC) plastics to increase flexibility, can leach from the plastic during exposure to blood and blood components (1)(2)(3)(4)(5)(6). PVC plastic is used in a great variety of medical devices, such as tubing for whole blood collection, bags for collection and storage of red cells, platelet concentrates (PC), or plasma, hemodialysis setups, tubing for intravenous injections, cytapheresis, plasma exchange and plasmapheresis.…”
Section: Introductionmentioning
confidence: 99%
“…DEHP has been reported to accumulate in whole blood, stored at 4°C, at a rate of 0.25 mg/100 mUd. 3 After 21 days of storage, concentration of DEHP would reach 55 ppm, representing 26-28 mg of DEHP in each unit of blood. Therefore, a patient who is infused with plasma or whole blood from a PVC ALAN F. KAUL container, or who is exposed to a PVC device (e.g., intravenous tubing) through which blood circulates, would receive a significantly larger amount of DEHP than a patient receiving a comparable volume of aqueous solution.…”
Section: Fate and Metabolism Of Dehpmentioning
confidence: 99%
“…Toxicity of DEHP could be due to: (1) the alcohol, (2) phthalic acid, (3) ester, or (4) a combination of these factors. 7 DEHP has an extremely low order of toxicity; in several animal models, doses of -50 g/kg are required to produce an LD 50 .15 DEHP would, thus, be classified as "practically nontoxic" by the toxicity rating system of Gleason and her colleagues.…”
Section: Toxicologymentioning
confidence: 99%
“…The plasticizer used, tri-(2-ethylhexyl) trimellitate (TOTM) leaches in very small amounts from the plas tic into the contained blood, in contrast to the plasticizer currently in use, di-(2-ethylhexyl)phthalate (DEHP) [1][2][3]. Some plas tics have been shown to exert a detrimental effect on platelets [4] during storage, and for this reason it was decided to compare the survival of platelets collected into the new formulation packs with platelets collected into the present standard packs.…”
Section: Introductionmentioning
confidence: 99%