Recent developments in the use of natural product-based molecules as antiparasitic
agents for Malaria, leishmaniasis (LE), Chagas disease (CD), and Human African trypanosomiasis
(HAT) are reviewed. The role of diverse plants in developing bioactive species is discussed in addition to analyzing the structural diversity of natural products as active agents and the diverse biological applications in CD, HAT, LE, and Malaria. This review focuses on medicinal chemistry,
emphasizing the structural characteristics of natural molecules as bioactive agents against parasitic
infections caused by Leishmania, Trypanosoma, and Plasmodium parasites.