Acceleration of segmental bone regeneration in a rabbit model by strontium-doped calcium polyphosphate scaffold through stimulating VEGF and bFGF secretion from osteoblasts

Gu, Zhipeng; Zhang, Xu; Li, Li; Wang, Qiguang; Yu, Xixun; Feng, Ting

doi:10.1016/j.msec.2012.08.040

Cited by 50 publications

(23 citation statements)

References 48 publications

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“…The interesting properties of CPP in solution and in the solid state offer a wide range of applications for tissue engineering and drug delivery . CPP represents a promising bone graft substitute because of its biocompatibility, mechanical strength, stimulation of bone healing and slow degradation . The in vivo degradation of CPP can be affected by (1) size of particles from which the scaffold was formed; (2) scaffold microstructure, such as pore size, porosity and crystal type, and (3) implantation site …”

Section: Introductionmentioning

confidence: 99%

“…18,[20][21][22][23][24][25][26] CPP represents a promising bone graft substitute because of its biocompatibility, 27 mechanical strength, stimulation of bone healing and slow degradation. 17,18,23,25,[28][29][30][31][32] The in vivo degradation of CPP can be affected by (1) size of particles from which the scaffold was formed; (2) scaffold microstructure, such as pore size, porosity and crystal type, and (3) implantation site. 28 The unique structure allows CPP to behave as a polymer to some extent.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Particle Size and Soaking Conditions on Rheology and Microstructure of Amorphous Calcium Polyphosphate Hydrogel

et al. 2015

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Amorphous calcium polyphosphate (ACPP), an inorganic polymer ceramic, has shown promise as a drug delivery matrix following a repeat gelling protocol. This study described a simple method of preparing ACPP hydrogel in the presence of an excess volume of water. The increased water availability accelerates water molecule ingress and microstructural transformation of ACPP hydrogels. The impact of some experimental settings (soaking time, temperature, stirring, and ACPP particle size) on the physiochemical and rheological natures of ACPP hydrogel were investigated and from which possible hydrogel formation mechanisms were inferred. We believe that the formation of ACPP hydrogel is through the mechanisms of intermolecular ionic interaction and entanglement of polyphosphate chains. The potential application of ACPP hydrogel as a ceramic matrix for sustained drug release warrants further investigation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Particle Size and Soaking Conditions on Rheology and Microstructure of Amorphous Calcium Polyphosphate Hydrogel

et al. 2015

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“…It may accelerate proliferation and differentiation of osteoblastic cell lineage and stimulate VEGF release from osteoblasts. This indicates that Sr promotes neovascularization and improves new bone formation (17). Chen et al, used biodegradable strontium doped calcium polyphospshate (CPP) to promote the adhesion and spread of endothelial cells.…”

Section: Induction Of Angiogenesis Strontium Can Stimulate Neoangiogementioning

confidence: 99%

Does Local Application of Strontium Increase Osteogenesis and Biomaterial Osteointegration in Osteoporotic and Other Bone Tissue Conditions: Review of Literature

Zariņš¹,

Pilmane

Sidhoma

et al. 2016

Acta Chirurgica Latviensis

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SummaryOsteoporosis and other pathological bone conditions can impair bone regeneration properties, consuming in increased morbidity and decreased quality of life. Changes of bone healing can result in poor osteointegration and surgical failures if implants are used. To overcome and facilitate bone regeneration, more attempts are made to develop an ideal synthetic scaffold with better biocompatibility, osteoconductivity, bioactivity, osteoinductivity and interconnected porosity. It is considered that strontium, being similar to calcium, can be incorporated into the mineral phase of the bone remodeling. This quality had led strontium to be used as an osteoporotic medication to improve quality of bone and to reduce the risk of bone fractures. Also local application of strontium has been widely used within different biomaterials in tissue engineering researches.In this review authors wanted to provide an overview about strontium, its mechanisms of action in bone tissue and initiated changes of bone remodeling within biomaterials.

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“…According to open literature, the release of therapeutic ions enhances the bioactivity of the glasses related to both osteogenesis and angiogenesis . Among many therapeutically active ions, strontium has the ability to substitute calcium in the mineral phase of natural bone tissue and is promoting osteoblast‐related bone formation while inhibiting osteoclast‐related bone resorption . Meanwhile, copper has antibacterial activity, as well as enhancing angiogenesis .…”

Section: Introductionmentioning

confidence: 99%

“…5 Among many therapeutically active ions, strontium has the ability to substitute calcium in the mineral phase of natural bone tissue 6,7 and is promoting osteoblast-related bone formation while inhibiting osteoclast-related bone resorption. [8][9][10][11][12][13][14][15] Meanwhile, copper has antibacterial activity, as well as enhancing angiogenesis. [16][17][18][19] Biological performance of Sr-doped 20,21 and Cu-doped 22 bioactive silicate glasses have been investigated in the literature.…”

Section: Introductionmentioning

confidence: 99%

Crystallization behavior of 45S5 bioactive glass modified by therapeutic ions

Taygun

Hocaoğlu

2017

Int J of Appl Glass Sci

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This is the first study that investigates the crystallization behavior of strontiumand copper-doped bioactive glasses by both isothermal and nonisothermal methods using differential thermal analysis (DTA) data. DTA results showed that bioactive glasses are suitable for glass-ceramic production. Isothermal and nonisothermal DTA experiments indicated that the crystallization activation energies of strontium-doped bioactive glasses are in the range of 304.1-327.7 kJ/mol, whereas the activation energies of copper-doped bioactive glasses change in the range of 219.13-263.20 kJ/mol. It was found that crystallization activation energies of strontium-doped glasses are higher than those of the copper-doped glasses.Avrami exponent, n, values of bioactive glasses showed that the bulk crystallization was found to predominate in all samples. Results revealed that isothermal and nonisothermal crystallization kinetics of strontium-and copper-doped bioactive glasses are in agreement within the experimental error. The first and well-studied composition was Bioglassâ 45S5, which contains 45% SiO 2 , 24.5% Na 2 O, 24.5% CaO, and 6% P 2 O 5 (in wt.%). Other bioactive glasses are derived from Bioglassâ. Critical concentrations of soluble Si, Ca, P, and Na ions that stimulate favorable intracellular and extracellular responses resulting in rapid bone formation are released through interfacial and cell-mediated reactions when bioactive glasses are implanted or in contact with biological fluids. Thereby, a carbonated hydroxyapatite (HCA) layer that provides bioactive glass to be chemically bond to host bone is developed on bioactive glass surface.3,4 Furthermore, bioactive glasses have also been reported to support enzyme activity, vascularization, foster osteoblast adhesion, growth, and differentiation, and to stimulate the differentiation of mesenchymal cells into osteoblasts. 4 Experimental studies showed that ionic dissolution products from bioactive glasses are key to understand the behavior of these materials in vitro and in vivo. According to open literature, the release of therapeutic ions enhances the bioactivity of the glasses related to both osteogenesis and angiogenesis.

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Acceleration of segmental bone regeneration in a rabbit model by strontium-doped calcium polyphosphate scaffold through stimulating VEGF and bFGF secretion from osteoblasts

Cited by 50 publications

References 48 publications

Influence of Particle Size and Soaking Conditions on Rheology and Microstructure of Amorphous Calcium Polyphosphate Hydrogel

Influence of Particle Size and Soaking Conditions on Rheology and Microstructure of Amorphous Calcium Polyphosphate Hydrogel

Does Local Application of Strontium Increase Osteogenesis and Biomaterial Osteointegration in Osteoporotic and Other Bone Tissue Conditions: Review of Literature

Crystallization behavior of 45S5 bioactive glass modified by therapeutic ions

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