Accelerating MR Imaging Liver Steatosis Measurement Using Combined Compressed Sensing and Parallel Imaging: A Quantitative Evaluation

Mann, Louis W.; Higgins, David M.; Peters, Carl; Cassidy, Sophie; Hodson, Kenneth; Coombs, Anna; Taylor, Roy; Hollingsworth, Kieren G.

doi:10.1148/radiol.2015150320

Cited by 35 publications

(39 citation statements)

References 39 publications

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“…For example the T2- SPAIR sequence used in image 3 might allow exclusion of the main pancreatic duct within the MR-opsy selection. As one of the major limiting factors for resolution of pancreas imaging is breath-hold duration, development of sparse scanning techniques which acquire data more rapidly may be expected to permit higher resolution imaging [61]. Under condition of severe pancreas fat infiltration of parenchymal tissues, the performance of the MR-opsy method alone can be limited.…”

Section: Discussionmentioning

confidence: 99%

Quantification of intrapancreatic fat in type 2 diabetes by MRI

et al. 2017

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ObjectivesAccumulation of intrapancreatic fat may be important in type 2 diabetes, but widely varying data have been reported. The standard quantification by MRI in vivo is time consuming and dependent upon a high level of experience. We aimed to develop a new method which would minimise inter-observer variation and to compare this against previously published datasets.MethodsA technique of ‘biopsying’ the image to minimise inclusion of non-parenchymal tissues was developed. Additionally, thresholding was applied to exclude both pancreatic ducts and intrusions of visceral fat, with pixels of fat values of <1% or >20% being excluded. The new MR image ‘biopsy’ (MR-opsy) was compared to the standard method by 6 independent observers with wide experience of image analysis but no experience of pancreas imaging. The effect of the new method was examined on datasets from two studies of weight loss in type 2 diabetes.ResultsAt low levels of intrapancreatic fat neither the result nor the inter-observer CV was changed by MR-opsy, thresholding or a combination of the methods. However, at higher levels the conventional method exhibited poor inter-observer agreement (coefficient of variation 26.9%) and the new combined method improved the CV to 4.3% (p<0.03). Using either MR-opsy alone or with thresholding, the new methods indicated a closer relationship between decrease in intrapancreatic fat and fall in blood glucose.ConclusionThe inter-observer variation for quantifying intrapancreatic fat was substantially improved by the new method when pancreas fat levels were moderately high. The method will improve comparability of pancreas fat measurement between research groups.

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Section: Discussionmentioning

confidence: 99%

Quantification of intrapancreatic fat in type 2 diabetes by MRI

et al. 2017

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“…Therefore, CSE‐MRI may help reduce scan time and could easily be applied to whole body imaging, In addition, whole body MRI can be used to identify occult inflammation and facilitate early diagnosis , and the method proposed here is likely to be much faster than existing spin echo‐based approaches. Even greater acceleration could be achieved using compressed sensing and parallel imaging techniques, as recently described . CSE‐MRI also might be used to generate whole body R2* maps, which could be applied to monitor structural damage and progression throughout the spine.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Quantification of Bone Edema/Adiposity and Structure in Inflamed Bone Using Chemical Shift‐Encoded MRI in Spondyloarthritis

Bray

Bainbridge

Punwani

et al. 2017

Magnetic Resonance in Med

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PurposeTo evaluate proton density fat fraction (PDFF) and R2* as markers of bone marrow composition and structure in inflamed bone in patients with spondyloarthritis.MethodsPhantoms containing fat, water, and trabecular bone were constructed with proton density fat fraction (PDFF) and bone mineral density (BMD) values matching those expected in healthy bone marrow and disease states, and scanned using chemical shift‐encoded MRI (CSE‐MRI) at 3T. Measured PDFF and R2* values in phantoms were compared with reference FF and BMD values. Eight spondyloarthritis patients and 10 controls underwent CSE‐MRI of the sacroiliac joints. PDFF and R2* in areas of inflamed bone and fat metaplasia in patients were compared with normal bone marrow in controls.ResultsIn phantoms, PDFF measurements were accurate over the full range of PDFF and BMD values. R2* measurements were positively associated with BMD but also were influenced by variations in PDFF. In patients, PDFF was reduced in areas of inflammation and increased in fat metaplasia compared to normal marrow. R2* measurements were significantly reduced in areas of fat metaplasia.ConclusionPDFF measurements reflect changes in marrow composition in areas of active inflammation and structural damage and could be used for disease monitoring in spondyloarthritis. R2* measurements may provide additional information bone mineral density but also are influenced by fat content. Magn Reson Med 79:1031–1042, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…The sparse imaging techniques described in the previous section have been applied for a number of clinical applications in body MRI, in order to increase imaging speed and improve performance (61,64,75–86). These studies include accelerated 3D abdominal MRI, free-breathing DCE-MRI, abdominal 4D flow imaging.…”

Section: Sparse Body Mri: Clinical Applicationsmentioning

confidence: 99%

Compressed sensing for body MRI

Feng

Benkert

Block

et al. 2016

Magnetic Resonance Imaging

236

180

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The introduction of compressed sensing for increasing imaging speed in MRI has raised significant interest among researchers and clinicians, and has initiated a large body of research across multiple clinical applications over the last decade. Compressed sensing aims to reconstruct unaliased images from fewer measurements than that are traditionally required in MRI by exploiting image compressibility or sparsity. Moreover, appropriate combinations of compressed sensing with previously introduced fast imaging approaches, such as parallel imaging, have demonstrated further improved performance. The advent of compressed sensing marks the prelude to a new era of rapid MRI, where the focus of data acquisition has changed from sampling based on the nominal number of voxels and/or frames to sampling based on the desired information content. This paper presents a brief overview of the application of compressed sensing techniques in body MRI, where imaging speed is crucial due to the presence of respiratory motion along with stringent constraints on spatial and temporal resolution. The first section provides an overview of the basic compressed sensing methodology, including the notion of sparsity, incoherence, and non-linear reconstruction. The second section reviews state-of-the-art compressed sensing techniques that have been demonstrated for various clinical body MRI applications. In the final section, the paper discusses current challenges and future opportunities.

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Accelerating MR Imaging Liver Steatosis Measurement Using Combined Compressed Sensing and Parallel Imaging: A Quantitative Evaluation

Cited by 35 publications

References 39 publications

Quantification of intrapancreatic fat in type 2 diabetes by MRI

Quantification of intrapancreatic fat in type 2 diabetes by MRI

Simultaneous Quantification of Bone Edema/Adiposity and Structure in Inflamed Bone Using Chemical Shift‐Encoded MRI in Spondyloarthritis

Compressed sensing for body MRI

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