2004
DOI: 10.1073/pnas.0407162101
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Abstract: Numerous studies demonstrate links between chronic stress and indices of poor health, including risk factors for cardiovascular disease and poorer immune function. Nevertheless, the exact mechanisms of how stress gets ''under the skin'' remain elusive. We investigated the hypothesis that stress impacts health by modulating the rate of cellular aging. Here we provide evidence that psychological stress-both perceived stress and chronicity of stress-is significantly associated with higher oxidative stress, lower … Show more

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Cited by 2,512 publications
(2,066 citation statements)
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References 25 publications
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“…We also did not find evidence, either within HC or schizophrenia gender-matched groups, that LTL is correlated with demographic or health variables that have often, but not always, been associated with LTL in other studies, e.g., perceived stress (Epel et al, 2004), education (Adler et al, 2013), socioeconomic status (Cherkas et al, 2006), tobacco use (Babizhayev et al, 2011), exercise/activity (Puterman et al, 2010), sleep (Prather et al, 2011), diet (Epel, 2009), depression , early life adversity (Price et al, 2013) and BMI (Epel, 2009). This suggests that each of these demographic, lifestyle, and health variables, despite the fact that they differed between groups, did not substantially contribute to our LTL findings.…”
Section: Discussioncontrasting
confidence: 94%
See 1 more Smart Citation
“…We also did not find evidence, either within HC or schizophrenia gender-matched groups, that LTL is correlated with demographic or health variables that have often, but not always, been associated with LTL in other studies, e.g., perceived stress (Epel et al, 2004), education (Adler et al, 2013), socioeconomic status (Cherkas et al, 2006), tobacco use (Babizhayev et al, 2011), exercise/activity (Puterman et al, 2010), sleep (Prather et al, 2011), diet (Epel, 2009), depression , early life adversity (Price et al, 2013) and BMI (Epel, 2009). This suggests that each of these demographic, lifestyle, and health variables, despite the fact that they differed between groups, did not substantially contribute to our LTL findings.…”
Section: Discussioncontrasting
confidence: 94%
“…Telomeres shorten with advancing age (Muezzinler et al, 2013) and are generally shorter in men than in women (Gardner et al, 2014). Telomeres also shorten with repeated mitosis in somatic cells, with replication-and nuclease-associated telomeric DNA damage, and with exposure to oxidative stress, certain cytotoxins, inflammation, and possibly stress hormones (Effros, 2011;Epel et al, 2004;Lindqvist et al, 2015;von Zglinicki, 2002;Wolkowitz et al, 2011). Among the most important lifestyle-and experience-related factors that may impinge on LTL are stress (Epel, 2009;Epel et al, 2004), tobacco use (Babizhayev et al, 2011), exercise (Puterman et al, 2010); and diet (Epel, 2009;Freitas-Simoes et al, 2016), as well certain medical risk factors, such as visceral adiposity (Epel, 2009) (but see (Diaz et al, 2010)), metabolic stress (Epel, 2009) and certain chronic viral infections (e.g., cytomegalovirus) (Effros, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…In landmark studies, Epel and colleagues (Blackburn, Epel & Lin, 2015; Epel et al., 2004) identified the association between exposure to life stress, shortening of leukocyte telomeres, and mortality in humans. The discrepancy with our current results could be attributed to intrinsic factors such as tissue specificity, species, and gender in the measure of telomere length (Sanders & Newman, 2013).…”
Section: Discussionmentioning
confidence: 99%
“…Notably, a recent multicohort study of 1.7 million adults followed up for mortality (Stringhini et al., 2017) has recognized the effect of SES among other recognized WHO risk factors (i.e., smoking, obesity, diabetes, hypertension, alcohol intake) assigning it a notable 1.26 hazard ratio. Similarly, an association has been demonstrated between psychological stress, senescence as measured by telomere shortening, and increased mortality (Epel & Lithgow, 2014; Epel et al., 2004). Altogether, these evidences support the inclusion of failed “adaptation to stress,” as one of the so‐called Seven Pillars of Aging (Kennedy et al., 2014).…”
Section: Introductionmentioning
confidence: 99%
“…Telomeres, the end parts of chromosomes that consist of tandem repeats of noncoding DNA, shorten as part of normal aging (Blackburn, Epel, & Lin, 2015) and also due to various types of intrinsic and extrinsic factors (Blackburn & Epel, 2012; Epel et al., 2004). Shorter telomere length has been linked to human pathologies such as cardiovascular disease, stroke, diabetes, dementia, and immune dysfunction (Atzmon et al., 2010).…”
Section: Introductionmentioning
confidence: 99%