Accelerated fracture healing with teriparatide

Borges, João Lindolfo Cunha

doi:10.1590/2359-3997000000016

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…PTH promotes early chondrogenesis and also osteogenesis in fracture models, which may have favorable implications for treatment of DNFs. Indeed, several case reports suggest PTH(1‐34) may promote healing of DNFs . A non‐placebo‐controlled trial of elderly osteoporotic women with pelvic factures showed an increased rate of radiographic healing and some clinical improvements in those treated with PTH(1‐84) .…”

Section: Agents and Biological Pathways That Promote Fracture Healingmentioning

confidence: 99%

“…Indeed, several case reports suggest PTH(1-34) may promote healing of DNFs. [68][69][70] A non-placebo-controlled trial of elderly osteoporotic women with pelvic factures showed an increased rate of radiographic healing and some clinical improvements in those treated with PTH(1-84). 71 A placebocontrolled trial of PTH in patients with closed distal radius fractures failed to achieve its primary endpoint, but accelerated radiographic healing was observed at the lower dose tested.…”

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confidence: 99%

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Fracture healing physiology and the quest for therapies for delayed healing and nonunion

Kostenuik

Mirza

2016

Journal Orthopaedic Research

144

121

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Delayed healing and nonunion of fractures represent enormous burdens to patients and healthcare systems. There are currently no approved pharmacological agents for the treatment of established nonunions, or for the acceleration of fracture healing, and no pharmacological agents are approved for promoting the healing of closed fractures. Yet several pharmacologic agents have the potential to enhance some aspects of fracture healing. In preclinical studies, various agents working across a broad spectrum of molecular pathways can produce larger, denser and stronger fracture calluses. However, untreated control animals in most of these studies also demonstrate robust structural and biomechanical healing, leaving unclear how these interventions might alter the healing of recalcitrant fractures in humans. This review describes the physiology of fracture healing, with a focus on aspects of natural repair that may be pharmacologically augmented to prevent or treat delayed or nonunion fractures (collectively referred to as DNFs). The agents covered in this review include recombinant BMPs, PTH/PTHrP receptor agonists, activators of Wnt/β‐catenin signaling, and recombinant FGF‐2. Agents from these therapeutic classes have undergone extensive preclinical testing and progressed to clinical fracture healing trials. Each can promote bone formation, which is important for the stability of bridged calluses, and some but not all can also promote cartilage formation, which may be critical for the initial bridging and subsequent stabilization of fractures. Appropriately timed stimulation of chondrogenesis and osteogenesis in the fracture callus may be a more effective approach for preventing or treating DNFs compared with stimulation of osteogenesis alone. © 2016 The Authors. Journal of Orthopaedic Research published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society. J Orthop Res 35:213–223, 2017.

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Section: Agents and Biological Pathways That Promote Fracture Healingmentioning

confidence: 99%

mentioning

confidence: 99%

Fracture healing physiology and the quest for therapies for delayed healing and nonunion

Kostenuik

Mirza

2016

Journal Orthopaedic Research

144

121

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“…In human clinical trials, teriparatide administration has shown to accelerate callus formation and lessen the risk of nonunion, and improve fracture healing [14][15][16] . Theoretically, the positive impact of teriparatide in early callus formation and fracture healing is important for an early return of functional outcomes and for preventing late complications.…”

Section: Introductionmentioning

confidence: 99%

Comparison of functional outcomes between teriparatide and vitamin D3 in distal end radius fractures of osteoporotic patients

Samant¹,

Sane²,

Butala³

et al. 2021

JRPMS

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Objectives: The objective of this study was to evaluate and compare the efficacy of teriparatide (osteoanabolic agent) versus vitamin D3 supplementation to improve functional outcomes in osteoporotic patients with distal end radius fractures (DERF). Methods: We conducted a prospective, randomized clinical study to compare the functional outcomes. Sixty osteoporotic DERF patients, treated with either conservative or surgical management were randomized to receive either teriparatide (20 mcg/day) or vitamin D3 (1000 IU/day) for a period of 3 months, along with calcium (500 mg/day) supplementation. The treatment outcomes were evaluated pre and post-management (1-month and 3-months) by Green and O’Brien scale, Patient-rated Wrist Evaluation (PRWE) scale, and Sarmiento scale. Results: There was a significant difference between the two groups at 3-months post-management. Teriparatide showed a significantly greater improvement of functional outcome (P=0.036) and patient-reported outcome (P<0.001) in comparison to vitamin D3 in total Green and O’Brien score and PRWE score, respectively. Conclusion: Teriparatide supplementation was effective and resulted in greater improvement in functional and radiologic outcomes in comparison to vitamin D3. Adjuvant teriparatide therapy may be a therapeutic option to improve the functional outcomes in DERF of osteoporotic patients.

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Effectiveness of parathyroid hormone (PTH) analogues on fracture healing: a meta-analysis

et al. 2021

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Accelerated fracture healing with teriparatide

Cited by 5 publications

References 2 publications

Fracture healing physiology and the quest for therapies for delayed healing and nonunion

Fracture healing physiology and the quest for therapies for delayed healing and nonunion

Comparison of functional outcomes between teriparatide and vitamin D3 in distal end radius fractures of osteoporotic patients

Effectiveness of parathyroid hormone (PTH) analogues on fracture healing: a meta-analysis

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