Acanthosis Nigricans

Knowles, Frank Crozer

doi:10.1001/archderm.1929.02380210046004

Cited by 11 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although this factor cannot be ignored, the appearance and resolution of the AN correlated directly with the girl's thyroid status. This association was described previously, but not discussed (9,10,20). From the veterinary literature, hypothyroid dachshund dogs also develop AN, which improves with thyroid therapy (25).…”

Section: Discussionmentioning

confidence: 70%

See 1 more Smart Citation

Remission of Acanthosis Nigricans, Hypertrichosis, and Hashimoto's Thyroiditis with Thyroxine Replacement

Fuenning

1986

Pediatric Dermatology

View full text Add to dashboard Cite

Hypothyroidism is not commonly associated with acanthosis nigricans (AN). We examined a 13-year-old girl with AN, hypertrichosis, and Hashimoto's thyroiditis. Overt biochemical hypothyroidism, thyroid enlargement, and positive titers of antimicrosomal and antithyroglobulin antibodies confirmed Hashimoto's thyroiditis. Both AN and hypertrichosis resolved with thyroid hormone replacement. There was no evidence of insulin resistance, polycystic ovarian disease, lipoatrophy, or other endocrine dysfunction, or of malignancy. In two patients from the literature with AN and hypothyroidism, AN was attributed to associated thyroid carcinoma or insulin resistance, rather than coexisting hypothyroidism. Since the skin lesions improved with thyroid hormone therapy in those two patients and in ours, hypothyroidism appears to be directly involved in the pathogenesis of AN.

show abstract

Section: Discussionmentioning

confidence: 70%

“…Only a few reports of AN in association with hypothyroidism have been published. In 1928 Knowles (20) described a patient with both conditions whose basal metabolic rate was -15%. The skin lesions in this patient improved with administration of thyroid hormone extract.…”

Section: Discussionmentioning

confidence: 99%