Acanthosis nigricans-like hyperpigmentation secondary to triazinate therapy

Introduction of a novel quantitative scoring system for acanthosis nigricans and its validation in a pilot study

“…Even excluded from the study were subjects with a history of drug use which can cause AN (orally nicotinic acid, oral contraceptives, testosterone, triazinate, or topically fusidic acid) as well as subjects who were pregnant or breast feeding, unable to give a cohesive history, had a high alcohol intake (>14 units/week for women and >21 units/week for men), or used illicit drugs. [17][18][19] The including and excluding criteria are listed in Table 1. any one of the following criteria: HbA1c value of ≥6.5%, or fasting glucose (≥126 mg/dL), or 2-hour glucose (≥200 mg/dL), or random glucose (≥200 mg/dL) in patients with classic symptoms of DM.…”

Introduction of a novel quantitative scoring system for acanthosis nigricans and its validation in a pilot study

“…Even excluded from the study were subjects with a history of drug use which can cause AN (orally nicotinic acid, oral contraceptives, testosterone, triazinate, or topically fusidic acid) as well as subjects who were pregnant or breast feeding, unable to give a cohesive history, had a high alcohol intake (>14 units/week for women and >21 units/week for men), or used illicit drugs. [17][18][19] The including and excluding criteria are listed in Table 1. any one of the following criteria: HbA1c value of ≥6.5%, or fasting glucose (≥126 mg/dL), or 2-hour glucose (≥200 mg/dL), or random glucose (≥200 mg/dL) in patients with classic symptoms of DM.…”

Reticulate, Patchy and Mottled Pigmentation of the Neck

“…In this case significant pigment deposits were also found in the eye lens and cornea. Acanthosis-nigricans-like hyperpigmentation involving also the neck, secondary to triazinate therapy, a folic acid antagonist, has been reported [49]. Widespread reticulate pigmentation after systemic therapy with 5-fluorouracil was observed by Allen et al [50].…”

Acanthosis nigricans: A new cutaneous sign in severe atopic dermatitis and Down syndrome

“…AN is characterized by hyperkeratosis, pigmentation and papillomatous elevation that give the affected skin a velvety texture. AN has been classified into five different types, including: (i) hereditary benign AN; 1 (ii) benign AN; (iii) pseudoacanthosis nigricans; 2 (iv) drug‐induced AN; 3 and (v) malignant AN 4 . Numerous disorders have been associated with AN, many of which involve tissue resistence to insulin 5–8 .…”

Introduction of a novel quantitative scoring system for acanthosis nigricans and its validation in a pilot study

“…Even excluded from the study were subjects with a history of drug use which can cause AN (orally nicotinic acid, oral contraceptives, testosterone, triazinate, or topically fusidic acid) as well as subjects who were pregnant or breast feeding, unable to give a cohesive history, had a high alcohol intake (>14 units/week for women and >21 units/week for men), or used illicit drugs. [17][18][19] The including and excluding criteria are listed in Table 1. any one of the following criteria: HbA1c value of ≥6.5%, or fasting glucose (≥126 mg/dL), or 2-hour glucose (≥200 mg/dL), or random glucose (≥200 mg/dL) in patients with classic symptoms of DM.…”

Reticulate, Patchy and Mottled Pigmentation of the Neck

“…In this case significant pigment deposits were also found in the eye lens and cornea. Acanthosis-nigricans-like hyperpigmentation involving also the neck, secondary to triazinate therapy, a folic acid antagonist, has been reported [49]. Widespread reticulate pigmentation after systemic therapy with 5-fluorouracil was observed by Allen et al [50].…”

Acanthosis nigricans: A new cutaneous sign in severe atopic dermatitis and Down syndrome

“…AN is characterized by hyperkeratosis, pigmentation and papillomatous elevation that give the affected skin a velvety texture. AN has been classified into five different types, including: (i) hereditary benign AN; 1 (ii) benign AN; (iii) pseudoacanthosis nigricans; 2 (iv) drug‐induced AN; 3 and (v) malignant AN 4 . Numerous disorders have been associated with AN, many of which involve tissue resistence to insulin 5–8 .…”

Introduction of a novel quantitative scoring system for acanthosis nigricans and its validation in a pilot study

“…Even excluded from the study were subjects with a history of drug use which can cause AN (orally nicotinic acid, oral contraceptives, testosterone, triazinate, or topically fusidic acid) as well as subjects who were pregnant or breast feeding, unable to give a cohesive history, had a high alcohol intake (>14 units/week for women and >21 units/week for men), or used illicit drugs. [17][18][19] The including and excluding criteria are listed in Table 1. any one of the following criteria: HbA1c value of ≥6.5%, or fasting glucose (≥126 mg/dL), or 2-hour glucose (≥200 mg/dL), or random glucose (≥200 mg/dL) in patients with classic symptoms of DM.…”

Reticulate, Patchy and Mottled Pigmentation of the Neck

“…In this case significant pigment deposits were also found in the eye lens and cornea. Acanthosis-nigricans-like hyperpigmentation involving also the neck, secondary to triazinate therapy, a folic acid antagonist, has been reported [49]. Widespread reticulate pigmentation after systemic therapy with 5-fluorouracil was observed by Allen et al [50].…”

Acanthosis nigricans: A new cutaneous sign in severe atopic dermatitis and Down syndrome

“…AN is characterized by hyperkeratosis, pigmentation and papillomatous elevation that give the affected skin a velvety texture. AN has been classified into five different types, including: (i) hereditary benign AN; 1 (ii) benign AN; (iii) pseudoacanthosis nigricans; 2 (iv) drug‐induced AN; 3 and (v) malignant AN 4 . Numerous disorders have been associated with AN, many of which involve tissue resistence to insulin 5–8 .…”