Açaí (<i>Euterpe oleracea</i>Mart.) presents anti-neuroinflammatory capacity in LPS-activated microglia cells

Souza, Diulie Valente de; Pappis, Lauren; Bandeira, Thuany Teixeira; Sangoi, Gabriela Geraldo; Fontana, Tuyla; Rissi, Vitor Braga; Sagrillo, Michele Rorato; Duarte, Thiago; Bodenstein, David; Andreazza, Ana Cristina; Cruz, Ivana Beatrice Mânica da; Ribeiro, Euler Esteves; Antoniazzi, Alfredo Q.; Ourique, Aline Ferreira; Machado, Alencar Kolinski

doi:10.1080/1028415x.2020.1842044

Cited by 13 publications

(19 citation statements)

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“…The vulnerability of the brain to oxidative stress, in addition to its energy requirements for neurotransmission, greatly increases the risk of mitochondrial dysfunction in neural tissue [ 69 ]. Data supports the correlation between mitochondrial dysfunction and neuronal death in NDDs [ 155 ]. Additionally, the current literature has linked the pathophysiology and cellular modifications of neuropsychiatric illnesses, such as bipolar disorder (BD) and schizophrenia (SCZ), to mitochondrial dysfunction and oxidative stress, respectively [ 67 ].…”

Section: Biological and Pharmacological Effectssupporting

confidence: 76%

“…There are limited investigations examining the impact of açaí berry on cognitive function or brain health. The experiments available have established that açaí largely confers its neuroprotection through antioxidant and anti-inflammatory mechanisms, restoration of mitochondrial function, and inhibition of toxic protein aggregation [ 152 , 153 , 154 , 155 ]. Antioxidants have a clear role in the neutralization of free radicals and, therefore, the protection of cells against oxidative damage caused by free radicals [ 14 ].…”

Section: Biological and Pharmacological Effectsmentioning

confidence: 99%

“…Oxidative damage has been linked to the development of chronic illnesses and is the common cytopathology of many neurodegenerative diseases (NDDs) [ 156 , 157 ]. Neuronal degradation and the development of NDDs are generally multifactorial processes incited by a genetics, aging, and environmental factors linked to the progression of oxidative stress, chronic neuroinflammation, mitochondrial dysfunction, anomalous protein accumulation in brain tissues, and excitotoxicity [ 72 , 148 , 155 ]. Data have shown that neurons unequipped for adequate response to oxidative stress undergo apoptotic or necrotic death [ 69 ].…”

Section: Biological and Pharmacological Effectsmentioning

confidence: 99%

“…The anti-inflammatory potential of açaí extract was evaluated via an in vitro microglial model that substantiated its modulation of nucleotide oligomerization domain (NOD)-like receptor pyrin domain-containing 3 (NLRP3) inflammasome proteins and antioxidant pathways, augmentation of anti-inflammatory cytokines, and reduction of pro-inflammatory cytokines [ 155 ]. Microglia were exposed to LPS and nigericin, inducers of inflammation, then treated with açaí.…”

Section: Biological and Pharmacological Effectsmentioning

confidence: 99%

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Açaí (Euterpe oleracea Mart.) in Health and Disease: A Critical Review

et al. 2023

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The açaí palm (Euterpe oleracea Mart.), a species belonging to the Arecaceae family, has been cultivated for thousands of years in tropical Central and South America as a multipurpose dietary plant. The recent introduction of açaí fruit and its nutritional and healing qualities to regions outside its origin has rapidly expanded global demand for açaí berry. The health-promoting and disease-preventing properties of this plant are attributed to numerous bioactive phenolic compounds present in the leaf, pulp, fruit, skin, and seeds. The purpose of this review is to present an up-to-date, comprehensive, and critical evaluation of the health benefits of açaí and its phytochemicals with a special focus on cellular and molecular mechanisms of action. In vitro and in vivo studies showed that açaí possesses antioxidant and anti-inflammatory properties and exerts cardioprotective, gastroprotective, hepatoprotective, neuroprotective, renoprotective, antilipidemic, antidiabetic, and antineoplastic activities. Moreover, clinical trials have suggested that açaí can protect against metabolic stress induced by oxidation, inflammation, vascular abnormalities, and physical exertion. Due to its medicinal properties and the absence of undesirable effects, açaí shows a promising future in health promotion and disease prevention, in addition to a vast economic potential in the food and cosmetic industries.

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Section: Biological and Pharmacological Effectssupporting

confidence: 76%

Section: Biological and Pharmacological Effectsmentioning

confidence: 99%

Section: Biological and Pharmacological Effectsmentioning

confidence: 99%

Section: Biological and Pharmacological Effectsmentioning

confidence: 99%

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Açaí (Euterpe oleracea Mart.) in Health and Disease: A Critical Review

et al. 2023

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“…A study investigating antioxidant activity of different acai berry genotypes and commercial pulp found that all hydroethanolic extracts had a potent scavenging property in reducing ROS produced by hydrogen peroxide (H 2 O 2 ) in the human neuroblastoma SH-SY5Y cell line and no difference in the antioxidant activity was seen between different genotypes by ABTS and deoxyribose assays (51). Moreover, acai berry extract addition resulted in a significant reduction in ROS to the negative control levels in lipopolysaccharide (LPS)activated microglia (58,59). The behavioural analysis revealed that the consumption of commercial acai berry juice could improve neurobehavioral disturbance as a consequence of methylmercury (MeHg) as well as reduced lipid peroxidation and nitrite level induced by MeHg (70).…”

Section: Euterpe Precatoria (Ep) Andmentioning

confidence: 99%

Neuroprotective activities of acai berries (Euterpe sp.): A review

ALNasser

Mellor

2022

J Herbmed Pharmacol

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Dietary interventions rich in fruits and vegetables in aging people can reverse or mitigate age-related cognitive declines, delay the onset of neurodegenerative diseases (NDDs), and provide long-term health dividends. The novel food, popularly known as "Acai", is a berry belonging to the Euterpe genus of tropical palms trees and natively found in South America. Euterpe oleracea has been given much attention among scientists due to its high antioxidant capacity compared to other fruits and berries. Additionally, acai pulp composition analysis found that it contains various biologically active phytochemicals. In this review, we focused on current evidence relating to acai berry neuroprotection mechanisms and its efficacy in preventing or reversing neurodegeneration and age-related cognitive decline. A number of studies have illustrated the potential neuroprotective properties of acai berries. They have shown that their chemical extracts have antioxidant and anti-inflammatory properties and maintain proteins, calcium homeostasis, and mitochondrial function. Moreover, acai berry extract offers other neuromodulatory mechanisms, including anticonvulsant, antidepressant, and anti-aging properties. This neuromodulation gives valuable insights into the acai pulp and its considerable pharmacological potential on critical brain areas involved in memory and cognition. The isolated chemical matrix of acai berries could be a new substitute in research for NDD medicine development. However, due to the limited number of investigations, there is a need for further efforts to establish studies that enable progressing to clinical trials to consequently prove and ratify the therapeutic potential of this berry for several incurable NDDs.

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