Abundance of gut Prevotella at baseline and metabolic response to barley prebiotics

Sandberg, Jonna; Kovatcheva‐Datchary, Petia; Björck, Inger; Bäckhed, Fredrik; Nilsson, Anne

doi:10.1007/s00394-018-1788-9

Cited by 52 publications

(42 citation statements)

References 29 publications

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“…The baseline levels of Prevotella and Bacteroides were not predictive of the metabolic response. Furthermore, the subjects with a high ratio of Prevotella/Bacteroides displayed a lower insulin response compared to the subjects with a low ratio, independent of the intervention [31]. A similar study was conducted by Kovatcheva-Datchary et al, where the intake of barley kernel bread was compared with white wheat bread in 39 healthy participants in a short-term crossover study [32].…”

Section: Healthy Normal-weight Individualsmentioning

confidence: 76%

“…A plant-based diet rich in fiber has recently been linked to a Prevotella enterotype, whereas the Bacterioides enterotype was associated with a high intake of protein and fat [53,54]. In the study by Sandberg et al the Prevotella/Bacteroides ratio at baseline was not predictive of the metabolic response to grain intervention [31]. This was, with the exception of some participants, also the finding after intake of whole-grain in the study by Schuttle et al [39].…”

Section: Discussionmentioning

confidence: 89%

“…Five of the included studies have investigated the effect of fiber on gut microbiota and metabolic regulation in healthy, normal-weight individuals ( Table 2). In a study by Sandberg et al, fecal samples from 99 individuals were analyzed, and the abundance of Prevotella and Bacteroides was quantified [31]. The analysis method for the microbiota was qPCR of 16S rRNA genes.…”

Section: Healthy Normal-weight Individualsmentioning

confidence: 99%

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Dietary Fiber, Gut Microbiota, and Metabolic Regulation—Current Status in Human Randomized Trials

et al. 2020

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New knowledge about the gut microbiota and its interaction with the host’s metabolic regulation has emerged during the last few decades. Several factors may affect the composition of the gut microbiota, including dietary fiber. Dietary fiber is not hydrolyzed by human digestive enzymes, but it is acted upon by gut microbes, and metabolites like short-chain fatty acids are produced. The short-chain fatty acids may be absorbed into the circulation and affect metabolic regulation in the host or be a substrate for other microbes. Some studies have shown improved insulin sensitivity, weight regulation, and reduced inflammation with increases in gut-derived short-chain fatty acids, all of which may reduce the risk of developing metabolic diseases. To what extent a dietary intervention with fiber may affect the human gut microbiota and hence metabolic regulation, is however, currently not well described. The aim of the present review is to summarize recent research on human randomized, controlled intervention studies investigating the effect of dietary fiber on gut microbiota and metabolic regulation. Metabolic regulation is discussed with respect to markers relating to glycemic regulation and lipid metabolism. Taken together, the papers on which the current review is based, suggest that dietary fiber has the potential to change the gut microbiota and alter metabolic regulation. However, due to the heterogeneity of the studies, a firm conclusion describing the causal relationship between gut microbiota and metabolic regulation remains elusive.

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Section: Healthy Normal-weight Individualsmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 89%

Section: Healthy Normal-weight Individualsmentioning

confidence: 99%

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Dietary Fiber, Gut Microbiota, and Metabolic Regulation—Current Status in Human Randomized Trials

et al. 2020

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“…Prevotella copri and Enterococcus faecalis play significant roles in the metabolism of aspirin (Fig 6). The abundance of the Prevotella/Bacteroides may be beneficial for metabolism [9]. This may explain that the metabolic activity of aspirin in the high-altitude environment is inhibited.…”

Section: Plos Onementioning

confidence: 99%

Effects of intestinal flora on the pharmacokinetics and pharmacodynamics of aspirin in high-altitude hypoxia

Sun¹,

Zhang²,

Zhao³

et al. 2020

PLoS ONE

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Since hypobaric hypoxia significantly affects metabolic characteristics of intestinal flora, which plays an important role in the biotransformation of aspirin, high altitudes may influence the pharmacokinetics and therapeutic effects of aspirin in the intestines. In the present study, to test alterations of intestinal microbiota at high altitude comparing to that at low altitude, we analyzed rat feces from plain group and high-altitude group by 16S rRNA analysis. To detect concentrations of aspirin and salicylic acid, we established a reliable liquid chromatography tandem mass spectrometry method to measure aspirin and salicylic acid concentrations in fecal suspensions and plasma. Our study found that the plateau hypoxic environment caused a significant increase in Bacteroides in rat feces, while Corynebacterium, Prevotella, and Coprococcus were declined. In addition, compared with the plain group, the metabolic activity of fecal suspensions from the plateau group on aspirin was significantly reduced. More importantly, these changes in the intestinal microbiota led to increasing absorption of aspirin in the rats after rapidly ascent to the plateau, and a reduction in the pharmacodynamic index TXB2, which would possibly result in bleeding. In conclusion, our research provides new ideas for changes in plateau pharmacokinetics, and then guide the corresponding reduction in aspirin dose for the population quickly entering the plateau.

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“…Yet another short-term study (3 days) conducted with barley kernel bread showed that individuals who had higher Prevotella abundance responded to the dietary treatment and had improved glucose metabolism [30]. In a follow-up study it was defined that not the abundance of Prevotella per se but the Prevotella/Bacteroides ratio was the parameter capable of stratifying metabolic responders [73]. Furthermore, Prevotella has also been associated inversely with clinical parameters of obesity related low-grade inflammation, including lipopolysaccharide and high-sensitive C-reactive Protein (hs-CRP), as was reviewed recently [74].…”

Section: The Gut Microbiota As a Predictor Of Responsiveness To A Heamentioning

confidence: 99%

Biomarkers of a Healthy Nordic Diet—From Dietary Exposure Biomarkers to Microbiota Signatures in the Metabolome

Landberg

Hanhineva

2019

Nutrients

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Whole diets and dietary patterns are increasingly highlighted in modern nutrition and health research instead of single food items or nutrients alone. The Healthy Nordic Diet is a dietary pattern typically associated with beneficial health outcomes in observational studies, but results from randomized controlled trials are mixed. Dietary assessment is one of the greatest challenges in observational studies and compliance is a major challenge in dietary interventions. During the last decade, research has shown the great importance of the gut microbiota in health and disease. Studies have have both shown that the Nordic diet affects the gut microbiota and that the gut microbiota predicts the effects of such a diet. Rapid technique developments in the area of high-throughput mass spectrometry have enabled the large-scale use of metabolomics both as an objective measurement of dietary intake as well as in providing the final readout of the endogenous metabolic processes and the impact of the gut microbiota. In this review, we give an update on the current status on biomarkers that reflect a Healthy Nordic Diet or individual components thereof (food intake biomarkers), biomarkers that show the effects of a Healthy Nordic Diet and biomarkers reflecting the role of a Healthy Nordic Diet on the gut microbiota as well as how the gut microbiota or derived molecules may be used to predict the effects of a Healthy Nordic Diet on different outcomes.

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Abundance of gut Prevotella at baseline and metabolic response to barley prebiotics

Abstract: NCT02427555.

Cited by 52 publications

References 29 publications

Dietary Fiber, Gut Microbiota, and Metabolic Regulation—Current Status in Human Randomized Trials

Dietary Fiber, Gut Microbiota, and Metabolic Regulation—Current Status in Human Randomized Trials

Effects of intestinal flora on the pharmacokinetics and pharmacodynamics of aspirin in high-altitude hypoxia

Biomarkers of a Healthy Nordic Diet—From Dietary Exposure Biomarkers to Microbiota Signatures in the Metabolome

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