Abundance of colonized bacteria as causative agent of septicemia in neonates hospitalized in the N.I.C.U Ward at Ghaem hospital in Mashhad

Background Neonatal sepsis is accounted for 30-50% of annual neonatal deaths in developing countries. We performed a systematic review and meta-analysis study to evaluate the national prevalence and identification of the etiological pathogens of neonatal sepsis in Iran. Methods A comprehensive literature search was done on the national and international databases for studies published between 2000 and 2019. The DerSimonian and Laird random-effects model was used to calculate pooled prevalence estimates, with 95% confidence intervals (CIs). Subgroup analyses and meta-regressions regarding the gender, type of sepsis and time during were also performed. Data were extracted, analyzed, and presented according to PRISMA guideline. Results Of 944 publications identified, 22 studies containing 14,683 neonates met the eligibility criteria. The pooled national prevalence of sepsis in Iran was 15.98% (95%CI, 11.96-20.46%; 1,367/14,683). Prevalence rate in boys (20.42%; 95%CI, 9.03-34.8%) was slightly higher than girls (18.5%; 95%CI, 7.4-32.8). A decreasing trend in prevalence of neonatal sepsis was found in recent years, although not statistically significant (c =-0.005; P value = 0.4). The most prevalent causative bacterial pathogens were Enterobacter spp. (23.04%), followed by Klebsiella pneumoniae (17.54%), coagulase-negative Staphylococci (14.

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Neonatal sepsis in Iran: A systematic review and meta-analysis on national prevalence and causative pathogens

Rad

Riahi

Abdollahi

et al. 2020

PLoS ONE

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Abundance of colonized bacteria as causative agent of septicemia in neonates hospitalized in the N.I.C.U Ward at Ghaem hospital in Mashhad

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Neonatal sepsis in Iran: A systematic review and meta-analysis on national prevalence and causative pathogens

Neonatal sepsis in Iran: A systematic review and meta-analysis on national prevalence and causative pathogens

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