Abstract:Background: Four large randomized phase III trials have reported significant improvements in disease-free (DFS) and overall survival for H administered with adjuvant polychemotherapy for HER2-positive high-risk BC. With the success of HER2-targeting, limiting chemotherapy is both reasonable and feasible, particularly for smaller, node-negative tumors. However data are limited.
Methods: APT is a single arm three-stage, multicenter, phase II study of TH. Patients (pts) with HER2-positive BC (IHC 3… Show more
“…In the apt trial, 406 patients with node-negative, her2-positive tumours less than 3 cm in size were treated with weekly paclitaxel plus trastuzumab for 12 weeks, and then with every-3-weeks trastuzumab for 9 months. Recently presented early study results showed 98.7% disease-free survival at 3 years of follow-up 15 . The most common grade 3 or 4 adverse events were neutropenia (5% of patients) and neuropathy (3% of patients).…”
ConclusionsFor patients with non-metastatic breast cancer refusing alopecia, or for patients who are not candidates for standard chemotherapy, tv is a reasonable alternative to standard adjuvant chemotherapy.
“…In the apt trial, 406 patients with node-negative, her2-positive tumours less than 3 cm in size were treated with weekly paclitaxel plus trastuzumab for 12 weeks, and then with every-3-weeks trastuzumab for 9 months. Recently presented early study results showed 98.7% disease-free survival at 3 years of follow-up 15 . The most common grade 3 or 4 adverse events were neutropenia (5% of patients) and neuropathy (3% of patients).…”
ConclusionsFor patients with non-metastatic breast cancer refusing alopecia, or for patients who are not candidates for standard chemotherapy, tv is a reasonable alternative to standard adjuvant chemotherapy.
“…The three-year DFS rate was 98.7% (98% for patients with tumors >1 cm and 99.5% for those with tumors 61 cm), and the three-year RFS was 99.2%. After a median follow-up of 3.6 years, only 10 in a total of 406 patients experienced a recurrence or death, accounting for 2.5% of the population [44]. There are several limitations of this trial, such as the lack of randomization, the inclusion of patients with T1a tumors that are already associated with a very favorable prognosis and the predominance (67%) of HR+ tumors, among which recurrences can be expected beyond the time of follow-up for this study.…”
“…Mit dem Ziel, eine verträgliche Chemotherapie bei kleinen HER2-positiven Mammakarzinomen (<1 cm), die eine vergleichsweise problematische Prognose haben (bis zu 20% Rückfälle in den ersten 5 Jahren), zu entwickeln, wurde ein alleiniges Paclitaxel-Trastuzumab-Schema vorgestellt (Pac q1w *12 plus Trastuzumab 1 Jahr; [28] …”
Section: Therapie Des Kleinen Her2-positiven Mammakarzinomsunclassified
Die breite Anwendung adjuvanter Therapien beim frühen Mammakarzinom hat zu einer substanziellen Verbesserung der Prognose in allen Stadien geführt. Die Zehnjahresüberle-benswahrscheinlichkeit liegt inzwischen bei weit über 80%, sodass man von einer heilbaren Erkrankung sprechen kann.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.