Abstract:Intro: Sarcomatoid de-differentiation in renal cell carcinoma (sRCC) leads to aggressive tumors that may be uniquely responsive to adjuvant immunotherapy. sRCC is thought to arise by epithelial to mesenchymal transition (EMT) of the parental tumor, most commonly clear cell RCC (ccRCC). However, factors that drive sRCC are unknown and no biomarkers exist to predict the transition. Furthermore, the immune microenvironment in sRCC is not well understood and may provide additional therapeutic targets. Here, we use… Show more
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