Abstract:Doxorubicin (DOX) is a potent, commonly used anthracycline antibiotic for a wide range of cancers, but its dose is limited by its strong cardiotoxic effects. The glucose analog 2-deoxy-D-glucose (2-DG) has been shown to enhance the antitumor efficacy of DOX in tumor cell lines and in animals. However, the cardiac effects of 2-DG in these experiments were not determined. In the current study, we examined whether 2-DG could protect from DOX cardiotoxicity in a BALB/c mouse breast cancer model. A total of 32 mice… Show more
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