Abstract Number ‐ 273: Gender differences in comborbidities among acute ischemic stroke patients with heart failure and thrombolytic therapy.

Abstract

Introduction Aim: The purpose of this study is to determine risk factors that contribute to a gender difference in Acute Ischemic Stroke (AIS) patients with a past medical history of heart failure(HF) excluded from recombinant tissue plasminogen activator (rtPA). Methods Methods: The data for this analysis was extracted from the stroke registry of a regional stroke center from January 2010 until June 2016 in Greenville, SC. Data was analyzed using the logistic regression to identify factors significantly associated with exclusion receiving rtPA therapy in the AIS‐HF patient population stratified by gender. Results Results:A total of 590 AIS patients with HF that presented with AIS were identified. Factorsassociated with exclusion from rtPA for males included past history of antidepressants (OR = 0.728, 95% CI, 0.264‐2.012, P < 0.541), previous history of coronary artery stenosis (OR = 0.269,95%, Cl, 0.077‐0.941, P < 0.040). Factors associated with exclusion for females included age over75(OR = 0.975, 95% CI, 0.949‐1.000, P < 0.054), and history of chronic renal failure (OR = 0.235,95% CI, 0.078‐0.708, P < 0.010). Conclusions Conclusion: Our study identified risk factors that can be managed to eliminate gender difference and improve the eligibly of AIS patients with a history of heart failure for thrombolytic therapy.