Abstract A3: The human epidermal growth factor receptors in gastric carcinomas: A study using fluorescence in situ hybridization and immunohistochemistry
Abstract:The human epidermal growth factor receptors (EGFR) family consists of four members: ErbB-1 (HER1), ErbB-2 (HER2), ErbB-3 (HER3) and ErbB-4 (HER4). These receptors activate numerous downstream pathways in response of extracellular ligands, regulating diverse processes including differentiation, migration, proliferation, and survival. Alterations in EGFR family members play a role in the development and progression of many human cancers. In gastric carcinomas (GC), HER1 and HER2 overexpressions are thought to be… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.