Abstract:Background: Despite thyroid tumors are generally curable, a fraction of patients develops resistance to therapy and tumors progress towards undifferentiated forms, which have a poor prognosis and whose treatment is still a demanding challenge. To identify potential novel targets for thyroid cancer treatment, especially for those aggressive forms, we faced the non-oncogene addiction paradigm, which states that tumor cells become addicted to stress support pathway genes, not required to the same degree by normal… Show more
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