Abstract:Background: Sarcomatoid renal cell carcinoma (sRCC) is thought to arise by epithelial to mesenchymal transition (EMT) of the parental tumor in diverse RCC including clear cell RCC (ccRCC). sRCC is also known to be highly immunogenic and also express high levels of inflammatory pathway genes. Cells undergoing EMT and immune cells can have reciprocal feedback on each other; however, the role of such crosstalk in sRCC is unknown. Here, we use single cell spatial transcriptomics to evaluate the heterogeneity of EM… Show more
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