Abstract:Background: 5-Fu is a mainstay for treating colorectal carcinomas, despite modest efficacy/toxicity balance. Drug resistance and DPD-related toxicities are often limitations in clinical practice. To overcome this, we present a liposomal 5-FU designed to exhibit higher antiproliferative properties while being less affected by liver uptake and subsequent DPD-related toxicities. Methods: Formulation was optimized to allow proper stability while using time- and cost-effective manufacturing process. In vitro, antip… Show more
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