Abstract 278: Dual Modulation of Microscale Tissue Engineering and Energy Metabolism for Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes
Abstract:Background:
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) represent a viable cell source for clinical application and other purposes, such as disease modeling and drug discovery for cardiovascular diseases. However, their immature phenotype limits their utility for these applications. It is widely known that the transition from fetal to adult heart during development is accompanied by an alteration in energy metabolism from glycolysis to fatty acid oxidation (FAO), respectively. Usi… Show more
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