Abstract:Necrotic core formation during the development of atherosclerosis is associated with a chronic inflammatory response and promotes accelerated plaque development and instability. We hypothesized that sensing of necrotic cells by CLEC9A, a C-type lectin receptors selectively expressed by the CD8α
+
subset of dendritic cells (CD8α
+
DCs), plays a determinant role in the inflammatory response of atherosclerosis.
Reconstitution of lethally-irradia… Show more
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