Abstract:Background:
The calcineurin (Cn)/NF-AT signaling cascade plays a crucial role during T-cell activation and development of myocardial hypertrophy. We previously demonstrated that, in addition to NF-AT, Cn is translocated to the nucleus. We also developed a synthetic peptide (IBP) which inhibited the nuclear import of Cn without affecting calcineurin phosphatase activity. The antihypertrophic effect of IBP on the rat myocardium was shown
in vivo
and
in vitro
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