Abstract:Introduction:
Lack of efficient collateralisation during vascular occlusion leads to tissue ischemia in coronary, peripheral and cerebrovascular disease. Patients with peripheral, coronary, and cerebrovascular disease have elevated levels of the anti-angiogenic isoform of VEGF (VEGF-A
165
b), which correlate with poorer outcomes. In experimental animals, VEGF-A
165
b neutralisation improves blood flow and collateralisation after femoral or coronary ar… Show more
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