Absorption, Transport, and Bioavailability of Vitamin E and its Role in Pregnant Women

Gagné, A.; Wei, Shu Qin; Fraser, William D.; Julien, Pierre

doi:10.1016/s1701-2163(16)34118-4

Cited by 50 publications

(34 citation statements)

References 89 publications

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“…The placental transfer of vitamin E is by passive diffusion; its passage to the fetus is dependent on plasma lipid concentrations [Gagné et al 2009;Haga et al 1982;Martinez et al 1981;Hill and Longo, 1980]. Vitamin E levels rise throughout pregnancy in women [Leonard et al 1972], thus the concentrations in pregnant women at terms are approximately four to five times higher than those of newborns [Gagné et al 2009;Leonard et al 1972].…”

Section: Discussionmentioning

confidence: 99%

No association of maternal vitamin E intake with higher risk of cardiovascular malformations in children: a population-based case–control study

Szilasi

Bártfai²,

Bártfai³

et al. 2011

Therapeutic Advances in Drug Safety

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Abstract:Objective: In Hungary, vitamin E is frequently used to prevent repeated or threatened abortion. A previous study showed a higher risk of cardiovascular malformations in the children of pregnant women who had a high vitamin E intake either in their diet or by taking supplements. The objective was to examine this association. Methods: The Hungarian CaseControl Surveillance System of Congenital Abnormalities, 19801996, is a large, population-based dataset including 22,843 cases with congenital abnormalities, 38,151 healthy controls matched to the cases, and 834 patient controls with Down syndrome. Vitamin E treatment was compared in the mothers of these children. Results: The mothers of 1418 cases with congenital abnormalities (6.2%), 2267 controls (6.0%) and 43 patient controls (5.2%) had vitamin E treatment during pregnancy. A preliminary comparison of cases and controls showed a higher risk for four congenital abnormality groups, including cardiovascular malformations. However, if only prospectively and medically recorded vitamin E treatments in the prenatal maternity logbook were evaluated during the critical period of different congenital abnormalities, the higher risk for these congenital abnormalities was not found. Conclusions:The results of this study were based on relatively high-dose vitamin E intake in pregnant women and were not able to confirm the previously reported teratogenic effect of vitamin E.

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Section: Discussionmentioning

confidence: 99%

No association of maternal vitamin E intake with higher risk of cardiovascular malformations in children: a population-based case–control study

Szilasi

Bártfai²,

Bártfai³

et al. 2011

Therapeutic Advances in Drug Safety

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“…Even if a human meal contains a nutritionally-appropriate composition of compounds, the physiological utilization of individual components depends on its solubilisation from the food matrix, uptake from the small intestine and subsequent transformation into chylomicrons and lipoproteins [14, 15]. Plasma delivery of lipid-origin compounds (such as α-tocopherol) is also affected by body/tissue saturation with this compound [16].…”

Section: Introductionmentioning

confidence: 99%

Effect of Sea-Buckthorn (Hippophaë rhamnoides L.) Pulp Oil Consumption on Fatty Acids and Vitamin A and E Accumulation in Adipose Tissue and Liver of Rats

Czaplicki

Ogrodowska

Zadernowski

et al. 2017

Plant Foods Hum Nutr

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An in vivo experiment was conducted to determine the effect of sea-buckthorn pulp oil feeding on the fatty acid composition of liver and adipose tissue of Wistar rats and the liver accumulation of retinol, its esters and α-tocopherol. For a period of 28 days, rats were given a modified casein diet (AIN-93) in which sea-buckthorn pulp oil, soybean oil and pork lard were used as sources of fat. Compared to the other fat sources, sea-buckthorn pulp oil was the most abundant in C16 fatty acids, carotenoids (mainly β-carotene) and tocopherols (mainly α-tocopherol). Its consumption was reflected in an increased share of palmitoleic acid in adipose tissue and the liver and an increased level of retinol in liver tissues (this was not observed for its esters). Although the type of fat did not have a significant effect on the average content of α-tocopherol in the liver, the variation of saturation of this tissue with α-tocopherol was the lowest when rats were fed a diet containing sea-buckthorn oil. This experiment indicates the possibility of affecting adipose tissue and liver by a diet.

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“…Vitamin E levels rise throughout pregnancy in women [18]. The placental transfer of vitamin E is by passive diffusion; its passage to the fetus is dependent on plasma lipid concentrations.…”

Section: Discussionmentioning

confidence: 99%

Birth Outcomes of Pre-Eclamptic Pregnant Women With Vitamin E Supplementation A Population-Based Study

Bártfai¹,

Czeizel²,

Bánhidy³

2011

Open Drug Saf J

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Abstract:Objectives. To study the efficacy of vitamin E supplementation for the reduction of preterm birth/low birthweight newborns in pre-eclamptic pregnant women. Design. Comparison of the rate of preterm birth and low birthweight in pre-eclamptic pregnant women with or without vitamin E treatment. Setting. Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980Abnormalities, -1996. Population. Newborn infants in Hungarian population. Methods. Medically recorded pre-eclampsia and birth outcomes of pregnant women were evaluated. Main outcome measures. Preterm birth, low birthweight. Results. There was no lower incidence of pre-eclampsia after vitamin E treatment. Pregnant women with pre-eclampsia and without vitamin E treatment had a higher rate of preterm births (10.4% vs. 9.3%) and low birthweight newborns (7.8% vs. 5.6%) than the reference sample of 34,928 pregnant women without pre-eclampsia and without vitamin E treatment. The newborns of 936 pregnant women with pre-eclampsia and without vitamin E treatment had higher rate of preterm birth (10.4% vs. 8.6%; OR with 95% CI: 0.8, 0.7-0.9) than 81 pregnant women with pre-eclampsia but with vitamin E treatment. However, the rate of low birthweight newborns was somewhat but not significantly higher (8.6% vs. 7.8%; OR with 95 CI: 1.1, 0.8-1.4) in pregnant women with pre-eclampsia and with vitamin E treatment. There was very high rate of threatened abortion (45.7% vs. 15.3%) and threatened preterm delivery (27.2% vs. 13.5%) in 81 preeclamptic pregnant women with vitamin E treatment compared to the reference group. Conclusions. Vitamin E treatment reduced the rate of preterm birth in pregnant women with pre-eclampsia but not the rate of low birthweight newborns.

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Absorption, Transport, and Bioavailability of Vitamin E and its Role in Pregnant Women

Cited by 50 publications

References 89 publications

No association of maternal vitamin E intake with higher risk of cardiovascular malformations in children: a population-based case–control study

No association of maternal vitamin E intake with higher risk of cardiovascular malformations in children: a population-based case–control study

Effect of Sea-Buckthorn (Hippophaë rhamnoides L.) Pulp Oil Consumption on Fatty Acids and Vitamin A and E Accumulation in Adipose Tissue and Liver of Rats

Birth Outcomes of Pre-Eclamptic Pregnant Women With Vitamin E Supplementation A Population-Based Study

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