1958
DOI: 10.3181/00379727-97-23834
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Abstract: The successful use of topical steroid therapy for diseases of the skin. eye. and joints has led us to evaluate the effect of cortisol by rectum in iodiopathic ulcerative colitis. Truelove ( 1 ) and Allodi and lluratori ( 2 ) almost simultaneously reported good clinical results with cortisol enemas. but whether this was the result of systemic absorption of the steroid or a purely local effect was undetermined. Our experience with the clinical efficacy of this form of treatment will be reported in detail elsewhe… Show more

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Cited by 18 publications
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“…Cortisol itself was well absorbed from the recta of ulcerative colitis patients (Nabarro, Moxham, Walker & Slater, 1957), whereas the acetate and hemisuccinate were not (Nabarro et al 1957;Asher, 1958;Patterson & McGivney, 1959;Schwartz, Cohn, Bondy, Brodoff, Upton & Spiro, 1958;Truelove, 1958). However, cortisol acetate (Liddle, 1956) and prednisone (Staib, 1961) were absorbed in patients with healthy recta.…”
Section: Discussionmentioning
confidence: 88%
“…Cortisol itself was well absorbed from the recta of ulcerative colitis patients (Nabarro, Moxham, Walker & Slater, 1957), whereas the acetate and hemisuccinate were not (Nabarro et al 1957;Asher, 1958;Patterson & McGivney, 1959;Schwartz, Cohn, Bondy, Brodoff, Upton & Spiro, 1958;Truelove, 1958). However, cortisol acetate (Liddle, 1956) and prednisone (Staib, 1961) were absorbed in patients with healthy recta.…”
Section: Discussionmentioning
confidence: 88%