Absorption‐mode spectra on the dynamically harmonized Fourier transform ion cyclotron resonance cell

Qi, Yulin; Witt, Matthias; Jertz, R.; Baykut, Gökhan; Barrow, Mark P.; Nikolaev, E. N.; O’Connor, Peter B.

doi:10.1002/rcm.6311

Cited by 37 publications

(44 citation statements)

References 24 publications

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“…Thus, when combined with the infinity cell concept, both storage and excitation potential are close to the theoretical optimum. The performance is evaluated in a collaborative article between Bruker, the University of Warwick and Nikolaev …”

Section: Fourier Transform Ion Cyclotron Resonance Msmentioning

confidence: 99%

Ion traps in modern mass spectrometry

Nolting

Malek

Makarov

2017

Mass Spectrometry Reviews

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This review is devoted to trapping mass spectrometry wherein ions are confined by electromagnetic fields for prolonged periods of time within limited volume, with mass measurement taking place within the same volume. Three major types of trapping mass spectrometers are discussed, specifically radiofrequency ion trap, Fourier transform ion cyclotron resonance and Orbitrap. While these three branches are intricately interwoven with each other over their recent history, they also differ greatly in their fundamentals, roots and historical origin. This diversity is reflected also in the difference of viewpoints from which each of these directions is addressed in this review. Following the theme of the issue, we focus on developments mainly associated with the country of Germany but, at the same time, we use this review as an illustration of the rapidly increasing globalization of science and expanding multi-national collaborations.

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Section: Fourier Transform Ion Cyclotron Resonance Msmentioning

confidence: 99%

Ion traps in modern mass spectrometry

Nolting

Malek

Makarov

2017

Mass Spectrometry Reviews

View full text Add to dashboard Cite

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“…The mass spectrum was phase-corrected using the Autophaser 6.0 phase correction software [25][26][27][28][29][30][31][32]. All onedimensional (1D) spectra were first externally calibrated in the solariXControl software (Bruker Daltonics, Billerica, MA, USA) using Agilent ESI-L Low Concentration Tuning Mix (Agilent Technologies, Stockport, United Kingdom), and then internally calibrated against the theoretical m/z values of the ions generated by cholesterol using the quadratic calibration function within Data Analysis 4.0 (Bruker Daltonik GmbH, Bremen, Germany) [33].…”

Section: Control Mass Spectra and Product-ion Spectramentioning

confidence: 99%

Differentiating Fragmentation Pathways of Cholesterol by Two-Dimensional Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Agthoven

Barrow

Chiron³

et al. 2015

J. Am. Soc. Mass Spectrom.

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Abstract. Two-dimensional Fourier transform ion cyclotron resonance mass spectrometry is a data-independent analytical method that records the fragmentation patterns of all the compounds in a sample. This study shows the implementation of atmospheric pressure photoionization with two-dimensional (2D) Fourier transform ion cyclotron resonance mass spectrometry. In the resulting 2D mass spectrum, the fragmentation patterns of the radical and protonated species from cholesterol are differentiated. This study shows the use of fragment ion lines, precursor ion lines, and neutral loss lines in the 2D mass spectrum to determine fragmentation mechanisms of known compounds and to gain information on unknown ion species in the spectrum. In concert with high resolution mass spectrometry, 2D Fourier transform ion cyclotron resonance mass spectrometry can be a useful tool for the structural analysis of small molecules.

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“…Automated phase correction for absorption mode mass spectra was achieved with the development of the Autophaser software by Kilgour et al [34][35][36]. Phase correction for absorption mode mass spectrometry is now integral to data processing for FT-ICR MS, for various geometries of ICR cells [35,37]. Phasecorrected absorption-mode data from the dynamically harmonized ICR cell has allowed the highest published FT-ICR MS resolving power (R = 32,000,000 at m/z 400) [37].…”

Section: Introductionmentioning

confidence: 99%

“…Phase correction for absorption mode mass spectrometry is now integral to data processing for FT-ICR MS, for various geometries of ICR cells [35,37]. Phasecorrected absorption-mode data from the dynamically harmonized ICR cell has allowed the highest published FT-ICR MS resolving power (R = 32,000,000 at m/z 400) [37]. The effect of various instrument parameters on phase functions has also been studied [33].…”

Section: Introductionmentioning

confidence: 99%

Phase relationships in two-dimensional mass spectrometry

Agthoven

Kilgour

Lynch

et al. 2019

J. Am. Soc. Mass Spectrom.

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Two-dimensional mass spectrometry (2D MS) is a data-independent tandem mass spectrometry technique in which precursor and fragment ion species can be correlated without the need for prior ion isolation. The behavior of phase in 2D Fourier transform mass spectrometry is investigated with respect to the calculation of phase-corrected absorption-mode 2D mass spectra. 2D MS datasets have a phase that is defined differently in each dimension. In both dimensions, the phase behavior of precursor and fragment ions is found to be different. The dependence of the phase for both precursor and fragment ion signals on various parameters (e.g., modulation frequency, shape of the fragmentation zone) is discussed. Experimental data confirms the theoretical calculations of the phase in each dimension. Understanding the phase relationships in a 2D mass spectrum is beneficial to the development of possible algorithms for phase correction, which may improve both the signal-to-noise ratio and the resolving power of peaks in 2D mass spectra.

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Absorption‐mode spectra on the dynamically harmonized Fourier transform ion cyclotron resonance cell

Abstract: The manuscript demonstrates absorption-mode spectra from Nikolaev's ICR cell, which will be of interest to the community. The improved relative peak intensities and immediate identification of harmonic peaks will facilitate data interpretation.

Cited by 37 publications

References 24 publications

Ion traps in modern mass spectrometry

Ion traps in modern mass spectrometry

Differentiating Fragmentation Pathways of Cholesterol by Two-Dimensional Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Phase relationships in two-dimensional mass spectrometry

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