Absorption and Elimination of Thiouracil in Ruminants

Ely, Ray E.; Olson, Kenneth J.; Reineke, E. P.

doi:10.2527/jas1948.72208x

Cited by 4 publications

(3 citation statements)

References 0 publications

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“…However, this interpretation may be affected by the fact that the sheep in this experiment were drenched only once a day, blood samples being collected at the time of drenching. As Ely, Olsen, and Reineke (1948) showed that methyl thiouracil is eliminated within 24 hr from calves amd goats, it is possible that a diurnal variation of PBI concentration may be minimizing the extent of the changes seen. Unfortunately this point was not examined.…”

Section: Discussionmentioning

confidence: 99%

Hypothyroidism in the Sheep

Lascelles¹,

Setchell²

1959

Aust. Jnl. Of Bio. Sci.

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The effect of the oral administration of methyl thiouracil at three dose rates to pregnant ewes has been studied. Observations were made on foetal skeletal growth and maturity, foetal and maternal thyroid iodine, plasma-protein-bound iodine (PBI), cholesterol, phospholipid, total esterified fatty acids, and calcium. A retardation of osseous growth and a significantly greater retardation of osseous maturity was found. The thyroid iodine concentration in both ewes and foetuses and the maternal total thyroid iodine in all treated groups were decreased but the foetal total thyroid iodine was reduced only in the two highest dose rates. Significant reduction in the foetal FBI was found only with the two highest dose rates and no significant changes were found in the maternal FBI concentration. Increases in all lipid fractions and a decrease in calcium concentration were found in the foetal plasma in the treated groups.

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Section: Discussionmentioning

confidence: 99%

Hypothyroidism in the Sheep

Lascelles¹,

Setchell²

1959

Aust. Jnl. Of Bio. Sci.

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“…Schultze & Turner (1945) have investigated the toxicity of various goitrogens in animals, and they observed that thiourea and not thiouracil was markedly toxic to chicks, lambs, goats and cows. Thiouracil and other goitrogens are rapidly absorbed from the digestive tract and are rapidly eliminated mainly through the kidneys (Williams & Kay, 1944; Ely, Olson & Reineke, 1948).…”

Section: Synthetic Materials Available For the Study Of Thyroid Functmentioning

confidence: 99%

Thyroid Functions in Relation to Reproduction of Mammals and Birds

Maqsood¹

1952

Biological Reviews

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“…This shows that averages for one milking did not fully represent the effect of the thiouracil on phosphatase. This pronounced maximum in the milk phosphatase is probably attributable to ready penetration of the tissues by thiouracil and to rapid elimination of thiouracil by the kidneys (Ely, Olson & Reineke, 1948). An attempt was made to detect thiouracil in the milk by the method of Olson, Ely & Reineke (1947) but, in spite of satisfactory recoveries of thiouracil added to milk in vitro, none could be found.…”

Section: Estimation Of Equivalence Of Responses Of Phosphatase To Thimentioning

confidence: 99%