Absorbable versus nonabsorbable membranes and bone grafts in the treatment of ligature‐induced peri‐implantitis defects in dogs

Abstract

The purpose of this study was to clinically evaluate an absorbable collagen membrane (Bio-Gide) and a nonabsorbable polytetrafluoroethylene membrane (PTFE), associated or not with bone grafts, for the treatment of ligature-induced peri-implantitis defects in dogs. The bilateral mandibular premolars were removed from 5 2-year-old mongrel dogs. After 3 months of healing, 3 titanium implants were placed on each side of the mandible. Experimental peri-implantitis was induced after abutment connection. Ligatures and abutments were removed after 1 month and the bone defects were randomly assigned to one of the following treatments: DB: debridement alone; GBR+BG-I: debridement plus PTFE membrane associated with mineralized bone graft (Bio-Oss); GBR+BG-II: debridement plus collagen membrane (Bio-Gide) associated with mineralized bone graft; GBR-I: debridement plus PTFE membrane; GBR-II: debridement plus collagen membrane; BG: debridement plus mineralized bone graft. The peri-implant bone defects were measured before and 5 months after treatment. Results showed the greatest percentage of vertical bone fill for GBR+BG-II (27.77+/-14.07) followed by GBR-II (21.78+/-16.19), BG (21.26+/-6.87), GBR+BG-I (19.57+/-13.36), GBR-I (18.86+/-10.63) and DB (14.03+/-5.6). However, the values were not statistically significant (ANOVA, contrast F test, P=0.612). Within the limits of the present investigation, it can be concluded that no difference was detected among treatments.

Pre-clinical Models for Oral and Periodontal Reconstructive Therapies

“…Ligatures are typically removed after 2-3 mos, when approximately 30-50% of bone support is lost. Peri-implant bone defects are circumferential and wide, but rarely result in shallow craters (Lindhe et al, 1992;Grunder et al, 1993;Nociti et al, 2001a;Schwarz et al, 2007). The microflora associated with experimental peri-implantitis demonstrates many similarities to natural peri-implantitis lesions (Nociti et al, 2001b;Shibli et al, 2003).…”

“…In contrast, the microflora and the morphology are similar to the human situation, making this model suitable for studying the effects of NMF on the treatment of peri-implantitis. Consideration of biomaterials, biologics, and GBR techniques have been preferentially evaluated in these models (Nociti et al, 2001a;You et al, 2007). Potential endpoint measurements include percentage of vertical bone fill, height of new bone, and BIC (mm or %), as well as other parameters of osseointegration.…”

“…Reconstructive therapy includes removal of granulation tissue, treatment of the implant surfaces with abrasive instruments, and potential application of NMF as a regenerative therapy. Peri-implantitis defects treated with open-flap debridement alone show limited new bone formation and repair of about 15% of the vertical component of the defect (Grunder et al, 1993;Hürzeler et al, 1997;Nociti et al, 2001a). Histomorphometric analyses are usually performed on tissue samples harvested at 5 mos after reconstructive surgery.…”

Cureent Treatment Modalities for Peri-Implant Diseases.

“…Their results showed that debridement alone as well as grafting alone had the same effect as did either membrane. 26 However,Hurzeler and coworkers reported in an invitro canine study that guided bone regeneration procedures resulted in the greatest amount of new bone formation, followed by bone grafts alone, and flap debridement. 27 In humans, Roos-Jans˚aker et al were able to show similar response to therapy i.e implants pocket reduction of 2.9-3.4mm and new bone fill of 1.4-1.5mm for peri-implantitis sites treated with either bone grafts alone or bone grafts in conjunction with resorbable collagen membrane.…”

Reparação ao redor de implantes de titânio após regeneração óssea guiada com membrana reabsorvível

“…Outro fator importante é o volume final de osso neoformado alcançado pela ROG utilizando membrana reabsorvível, que apresentou resultados semelhantes àqueles obtidos com membrana de PTFE-e (Carpio et al, 2000;Nociti et al, 2001).…”