Absence of Mutations in Superoxide Dismutase and Catalase Genes in Patients With Parkinson's Disease

Abstract

Parkinson's disease is not caused by mutations in the genes of these three detoxifying enzymes. The exon 9 variant in the catalase gene in the one family with PD is most likely a silent mutation and not the genetic cause of PD in this family.

Predominant Genotypes and Alleles of Two Functional Polymorphisms in the Manganese Superoxide Dismutase Gene are Not Associated with Thai Cervical or Breast Cancer

“…In cancer patients and healthy women in Thailand studied herein, the Ile58Thr sequence change was not found and no other sequence variant was detected in exon-3 of MnSOD gene. Our data were in concordance with results of Grasbon-Frodl et al (1999) who reported the Ile/Ile variant only in 63 random German subjects as well as Parboosingh et al (1995) who failed to detect any sequence variation in exon-3 of the MnSOD gene by SSCP in 107 Parkinson disease patients including 40 sporadic and 67 familial cases.…”

Predominant Genotypes and Alleles of Two Functional Polymorphisms in the Manganese Superoxide Dismutase Gene are Not Associated with Thai Cervical or Breast Cancer

“…In cancer patients and healthy women in Thailand studied herein, the Ile58Thr sequence change was not found and no other sequence variant was detected in exon-3 of MnSOD gene. Our data were in concordance with results of Grasbon-Frodl et al (1999) who reported the Ile/Ile variant only in 63 random German subjects as well as Parboosingh et al (1995) who failed to detect any sequence variation in exon-3 of the MnSOD gene by SSCP in 107 Parkinson disease patients including 40 sporadic and 67 familial cases.…”

Tiron alleviates MPTP‐induced Parkinsonism in mice via activation of Keap‐1/Nrf2 pathway

“…[ 54 ] In addition, it has been reported that catalase activity decreased in the substantia nigra of PD patients. [ 47 ] This was confirmed by the data obtained from this study, where MPTP administration showed a marked elevation in the hippocampal MDA levels and therefore lipid peroxidation in the nigrostriatal region of brain concomitant with marked reduction in levels of catalase. Our results agreed with previous studies.…”

Genetic polymorphisms of superoxide dismutase in Parkinson's disease

“…We did find the C47T variant in exon 2 of SOD2 in our case and control samples. Contrary to a study in Japan,8 but consistent with studies of Caucasians in Europe,9, 10 we did not observe an association of the C47T polymorphism with PD. Discrepant findings among studies may be explained by ethnic differences in allelic frequencies between Asian and Caucasian populations.…”

Predominant Genotypes and Alleles of Two Functional Polymorphisms in the Manganese Superoxide Dismutase Gene are Not Associated with Thai Cervical or Breast Cancer

“…In cancer patients and healthy women in Thailand studied herein, the Ile58Thr sequence change was not found and no other sequence variant was detected in exon-3 of MnSOD gene. Our data were in concordance with results of Grasbon-Frodl et al (1999) who reported the Ile/Ile variant only in 63 random German subjects as well as Parboosingh et al (1995) who failed to detect any sequence variation in exon-3 of the MnSOD gene by SSCP in 107 Parkinson disease patients including 40 sporadic and 67 familial cases.…”

Tiron alleviates MPTP‐induced Parkinsonism in mice via activation of Keap‐1/Nrf2 pathway

“…[ 54 ] In addition, it has been reported that catalase activity decreased in the substantia nigra of PD patients. [ 47 ] This was confirmed by the data obtained from this study, where MPTP administration showed a marked elevation in the hippocampal MDA levels and therefore lipid peroxidation in the nigrostriatal region of brain concomitant with marked reduction in levels of catalase. Our results agreed with previous studies.…”

Genetic polymorphisms of superoxide dismutase in Parkinson's disease

“…We did find the C47T variant in exon 2 of SOD2 in our case and control samples. Contrary to a study in Japan,8 but consistent with studies of Caucasians in Europe,9, 10 we did not observe an association of the C47T polymorphism with PD. Discrepant findings among studies may be explained by ethnic differences in allelic frequencies between Asian and Caucasian populations.…”

Predominant Genotypes and Alleles of Two Functional Polymorphisms in the Manganese Superoxide Dismutase Gene are Not Associated with Thai Cervical or Breast Cancer

“…In cancer patients and healthy women in Thailand studied herein, the Ile58Thr sequence change was not found and no other sequence variant was detected in exon-3 of MnSOD gene. Our data were in concordance with results of Grasbon-Frodl et al (1999) who reported the Ile/Ile variant only in 63 random German subjects as well as Parboosingh et al (1995) who failed to detect any sequence variation in exon-3 of the MnSOD gene by SSCP in 107 Parkinson disease patients including 40 sporadic and 67 familial cases.…”

Tiron alleviates MPTP‐induced Parkinsonism in mice via activation of Keap‐1/Nrf2 pathway

“…[ 54 ] In addition, it has been reported that catalase activity decreased in the substantia nigra of PD patients. [ 47 ] This was confirmed by the data obtained from this study, where MPTP administration showed a marked elevation in the hippocampal MDA levels and therefore lipid peroxidation in the nigrostriatal region of brain concomitant with marked reduction in levels of catalase. Our results agreed with previous studies.…”

Genetic polymorphisms of superoxide dismutase in Parkinson's disease

“…We did find the C47T variant in exon 2 of SOD2 in our case and control samples. Contrary to a study in Japan,8 but consistent with studies of Caucasians in Europe,9, 10 we did not observe an association of the C47T polymorphism with PD. Discrepant findings among studies may be explained by ethnic differences in allelic frequencies between Asian and Caucasian populations.…”