Absence of human papillomavirus in squamous cell carcinomas of nongenital skin from immunocompromised renal transplant patients: a comment

Smith, Salli E.; Davis, Ira C.; Leshin, Barry; Fleischer, Alan B.; White, Wain L.; Feldman, Steven R.

doi:10.1001/archderm.131.1.107

Cited by 18 publications

(2 citation statements)

References 31 publications

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“…Furthermore, the percentage of mucosal types detected on the hands/fingers versus other sites was not specified in the study. HPV-16 is rarely found in non-genital, nondigital, CSCCs in healthy immunocompetent individuals 249,300. In another case-control study of immunocompetent individuals, DNA from beta-PV species 2 was found more frequently in CSCC than in adjacent healthy skin (OR = 4.0, 95% CI = 1.3–12), indicating a possible differential risk by specific beta-HPV types 301.…”

Section: Human Papillomavirus Virusmentioning

confidence: 98%

“…HPV-16 is rarely found in non-genital, nondigital, CSCCs in healthy immunocompetent individuals. 249,300 In another case-control study of immunocompetent individuals, DNA from beta-PV species 2 was found more frequently in CSCC than in adjacent healthy skin (OR = 4.0, 95% CI = 1.3-12), indicating a possible differential risk by specific beta-HPV types. 301 The results of this study are difficult to interpret, however, since 1) in situ hybridization to determine viral load was not performed, and 2) tissue samples apparently were not "stripped" to reduce surface contamination.…”

Section: Association Studiesmentioning

confidence: 99%

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The Combined Influence of Oral Contraceptives and Human Papillomavirus Virus on Cutaneous Squamous Cell Carcinoma

Efird

Toland

Lea

et al. 2011

Clin Med Insights Oncol

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The vast majority of cutaneous squamous cell carcinoma (CSCC) will occur in those with fair complexion, tendency to burn, and high ultraviolet radiation (UVR) exposure. Organ transplant recipients also are an important population at great risk for CSCC. An association has been reported between oral contraceptive (OC) use, human papillomavirus virus (HPV) and cervical cancer, and there could be a similar association for CSCC. The cutaneous HPV β-E6 protein, a close cousin of the transformative E6 protein underlying anogenital cancers, has been shown to inhibit apoptosis in response to UVR damage and stimulate morphologic transformation in rodent fibroblast cell lines. Furthermore, OC use has been shown to enhance HPV transcription and may contribute to CSCC risk through this pathway.

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Section: Human Papillomavirus Virusmentioning

confidence: 98%