1997
DOI: 10.1080/109158197226928 View full text |Buy / Rent full text
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Abstract: D e p a r t m e n t of Toxicolog y a n d Ter a t olog y, D e velop m e n t a l R es ea r ch L a b or a t or ie s , D a in ip p on P h a r m a ceu t ica l C o., L t d ., O s a k a , J a p a n Tox icit y s t u d ies w er e con d u ct ed t o ev a lu a t e a cu t e a n d su b ch ron ic or a l t ox icit y a n d m u t a gen icit y of p a r t i a l ly h y d r ol y z ed gu a r gu m (K -13 ). I n a n a cu t e t ox icit y s t u d y, m i ce a n d r a t s w ere t r ea t ed w i t h K -1 3 a t a d os e of 6 00 0 m g/ k g . … Show more

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“…With respect to thickeners -additives which maintain or increase texture and consistency, as well as stabilize the proteins and vitamins of industrialized foods -authorized for use in milk for children, according to ANVISA (Brasil, 2009) standards, guar gum, locust bean gum, carob gum, garrofin gum, jatai gum, pectin and amino pectin. Toxicity assessment studies have shown that guar gum (Takahashi et al, 1994;Koujitani et al, 1997;Kappor, Ishihara, & Okubo, 2016), locust bean gum (Meunier et al, 2014) and pectin (Kang et al, 2006;Khotimchenko, 2010) were not cytotoxic to the test systems to which they were tested. For the other thickeners mentioned, no toxicity assessment research was found at the cellular level.…”
Section: Resultsmentioning
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“…With respect to thickeners -additives which maintain or increase texture and consistency, as well as stabilize the proteins and vitamins of industrialized foods -authorized for use in milk for children, according to ANVISA (Brasil, 2009) standards, guar gum, locust bean gum, carob gum, garrofin gum, jatai gum, pectin and amino pectin. Toxicity assessment studies have shown that guar gum (Takahashi et al, 1994;Koujitani et al, 1997;Kappor, Ishihara, & Okubo, 2016), locust bean gum (Meunier et al, 2014) and pectin (Kang et al, 2006;Khotimchenko, 2010) were not cytotoxic to the test systems to which they were tested. For the other thickeners mentioned, no toxicity assessment research was found at the cellular level.…”
Section: Resultsmentioning
“…In an acute and sub-chronic oral toxicity study, PHGG at a dose of 6000 mg/kg for 13 weeks (Koujitani et al 1997) and 0, 500, and 2500 mg/kg/day for 28 days (Takahashi et al 1994) proved to have no toxic and mutagenic potential. Healthy female students administered 12.5 g/day of PHGG in their meal, no adverse reactions to the treatment reported (Sakata and Shimbo 2006).…”
Section: Haemolytic Effectsmentioning
“…An acute oral toxicity study on partially hydrolyzed guar was performed using groups of 16 (8 males and 8 females per group) 4-week-old Jcl: ICR mice and Jcl: SD rats. 50 Partially hydrolyzed guar was administered by gavage at a concentration of 30% in distilled water (dose = 6000 mg/kg body weight; dose volume = 20 mL/kg) to 1 group per species. The control group was dosed orally with distilled water.…”
Section: Toxicologymentioning
“…The 2 groups of 20 rats per sex were control (diet without partially hydrolyzed guar) and 5.0% partially hydrolyzed guar dietary groups, respectively. 50 The remaining 2 groups of 10 rats per sex received dietary concentrations of 0.2% and 1.0%. All groups were fed daily for 13 weeks.…”
Section: Toxicologymentioning