About invasive cervical cancer: a French population based study between 1998 and 2010

Lorin, Lydie; Bertaut, Aurélie; Hudry, Délphine; Beltjens, Françoise; Roignot, Patrick; Böne-Lépinoy, M.C.; Douvier, S.; Arveux, Patrick

doi:10.1016/j.ejogrb.2015.04.007

Cited by 22 publications

(27 citation statements)

References 12 publications

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“…It is worth emphasizing that in our series selected cases of FIGO stage IIB cervical cancer were qualified for radical hysterectomy, that is, those with early infiltration of the parametrium (only the proximal portion of the lateral parametria) and accompanying pathologies in the reproductive tract. The survival outcomes for the patients of the presented group were comparable with those reported by others [8,69] , which indirectly confirms the correctness of our decision.…”

Section: Discussionsupporting

confidence: 80%

Prognostic Parameters for Patients with Cervical Cancer FIGO Stages IA2-IIB: A Long-Term Follow-Up

Obrzut¹,

Semczuk

Naróg

et al. 2017

Oncology

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Objective: We assessed the prognostic factors related to 10-year overall survival and disease-free survival in cervical cancer patients that underwent primary surgical protocols in 1 institution. Materials and Methods: A total of 102 patients with uterine cervical cancer at FIGO stages IA2-IIB that underwent a Piver type III radical hysterectomy and pelvic lymphadenectomy between 1998 and 2001 were included. Univariate and multivariate analyses of 10-year overall survival and 10-year disease-free survival were performed. Results: Univariate analysis revealed that only lymphovascular space invasion significantly affected 10-year overall survival (p = 0.04), but it had no effect on the 10-year disease-free survival rate. Multivariate analysis demonstrated that survival rates were significantly affected by FIGO stage (p = 0.02, 95% CI: 1.18-5.55, for 10-year overall survival; p = 0.03, 95% CI: 1.07-6.12, for 10-year disease-free survival) and metastases to the pelvic lymph nodes (p = 0.0005, 95% CI: 1.81-8.53, for 10-year overall survival; p = 0.01, 95% CI: 1.26-7.24, for 10-year disease-free survival). Conclusions: The only independent prognostic factors for 10-year survival rates in patients with cervical cancer at FIGO stages IA2-IIB were clinical stage and presence of metastases to the pelvic lymph nodes. The presence of lymphovascular space invasion adversely affected 10-year overall survival.

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Section: Discussionsupporting

confidence: 80%

Prognostic Parameters for Patients with Cervical Cancer FIGO Stages IA2-IIB: A Long-Term Follow-Up

Obrzut¹,

Semczuk

Naróg

et al. 2017

Oncology

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“…In a recent study from the Burgundy Cancer Registry, significant prognostic factors identified were age, advanced stage and non-accurate follow-up (screening) [24]. The effect of the zone of residence on survival could be linked to access to cancer screening and cancer care in Martinique and will be explored in further studies.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and survival of cervical cancer in the French West-Indies: data from the Martinique Cancer Registry (2002–2011)

Melan

Janky

Macni

et al. 2017

Global Health Action

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Background: The Caribbean ranks seventh among world regions most affected by cervical cancer. Social health inequalities, such as differences in access to screening services, engender disparities in incidence and mortality between low- and middle-income countries and industrialized countries. The French National Cancer Plan 2014–2019 focuses on reducing inequalities in cervical cancer.Objective: The aim of this study was to describe the geographical distribution and overall survival of cervical cancer, based on data from a population-based cancer registry in Martinique (French West-Indies).Methods: We included all cases of cervical cancer diagnosed between 2002 and 2011. The geographical distribution was described by zone of residence and by aggregated units for statistical information (IRIS). Based on the results of the model, standardized incidence rates (SIRs) were calculated using a Gamma Poisson model. Survival rates were calculated using the Kaplan–Meier method. Cox proportional hazards models were used to investigate the risk factors for cervical cancer mortality.Results: A total of 1253 cases were analyzed (947 in situ tumors and 306 invasive cancers). 1230 cases with geolocalization were used to map the distribution of the incidence of in situ and invasive cervical cancers. Five IRIS were significantly over-incident. The 5-year overall survival rate was 55%, with a median survival of 6.5 years [95% CI: 4.9–10.1]. Multivariate analysis confirmed age at diagnosis (HR = 2.15 [1.50–3.09]; p < 0.0001), FIGO stage (HR = 3.53 [2.50–4.99]; p < 0.0001) and zone of residence (HR = 1.51 [1.06–2.13]; p = 0.02) as risk factors.Conclusions: Prognostic factors suggest that cervical cancer needs to be diagnosed at an early stage. Our results could allow cervical cancer screening programs to clearly identify geographical areas that would benefit from targeted interventions with a view to reducing incidence and mortality of cervical cancer in the Caribbean.

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“…Notably, with approximately 530,000 new cases and 275,000 deaths each year, CC is still one of the leading causes of cancer among women worldwide [ 2 ]. Principally, persistent infection with oncogenic human papillomavirus (HPV) is regarded as the main cause of CC, and early gene coding proteins of HPV can lead virus to tumorigenesis in host cells [ 3 ]. Furthermore, other risk factors such as precocious intercourse, multiple sexual partners, higher number of pregnancies, and smoking are involved in the incidence of CC [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Intrinsic and Extrinsic Factors on the Level of Hope and Psychological Health Status of Patients with Cervical Cancer During Radiotherapy

Lin

Liang

et al. 2017

Med Sci Monit

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BackgroundThis study aimed to explore the factors affecting the level of hope and psychological health status of patients with cervical cancer (CC) during radiotherapy.Material/MethodsA total of 480 CC patients were recruited. Psychological distress scale, Herth hope index, functional assessment cancer therapy-cervix, and Jolowiec coping scale were used to conduct surveys on psychological distress, level of hope, quality of life (QOL), and coping style to analyze the factors affecting the level of hope and psychological health status of CC patients.ResultsThe morbidity of significant psychological distress in 480 CC patients during radiotherapy was 68%, and the main factors causing psychological distress were emotional problems and physical problems. During radiotherapy, most patients had middle and high levels of hope, and the psychological distress index of patients was negatively correlated with the level of hope. The QOL of CC patients during radiotherapy were at middle and high levels, and the QOL was positively correlated with confrontment, optimism, appeasement, and self-reliance, but it was negatively correlated with predestination and emotional expression.ConclusionsFor CC patients during radiotherapy, the morbidity of psychological distress was high, but they were at middle and high levels of hope.

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About invasive cervical cancer: a French population based study between 1998 and 2010

Cited by 22 publications

References 12 publications

Prognostic Parameters for Patients with Cervical Cancer FIGO Stages IA2-IIB: A Long-Term Follow-Up

Prognostic Parameters for Patients with Cervical Cancer FIGO Stages IA2-IIB: A Long-Term Follow-Up

Epidemiology and survival of cervical cancer in the French West-Indies: data from the Martinique Cancer Registry (2002–2011)

Effects of Intrinsic and Extrinsic Factors on the Level of Hope and Psychological Health Status of Patients with Cervical Cancer During Radiotherapy

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