ABO, H, LE, P1PK, GLOB, I and FORS Blood Group Systems

doi:10.1002/9781118689943.ch4

Cited by 2 publications

(4 citation statements)

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“…This result supports the concept that gel card reactions are weaker in IgM anti-A and anti-B of groups B and A than in IgG anti-A and anti-B of group O. However, the proportion of ABO groups varies among populations [ 19 ]. While group A is the most common group in most areas, most South American Indians have group O, and B is the most frequent group in Bengalese [ 19 ].…”

Section: Discussionsupporting

confidence: 84%

“…In total, 35.4% (222/628) of Eflexis rejected cases in our study were neonates. Anti-A and/or anti-B antibodies generally appear after the first 3–6 months of life, which explains why the AB group showed the lowest RR compared with the O group in neonates [ 15 ]. The RR depends on the proportion of neonates in each hospital and on whether a specific neonatal/cord blood ABO grouping card is available or whether only the standard ABO/Rh grouping card is used.…”

Section: Discussionmentioning

confidence: 99%

“…However, the proportion of ABO groups varies among populations [ 19 ]. While group A is the most common group in most areas, most South American Indians have group O, and B is the most frequent group in Bengalese [ 19 ]. Therefore, the RRs of the Eflexis analyzer may vary among populations.…”

Section: Discussionmentioning

confidence: 99%

“…The authors recommended the manual tile method as a simple supplemental test for the detection of the cis -AB phenotype, especially in countries with a relatively high prevalence of cis -AB phenotypes [ 13 ]. To prevent hemolytic transfusion reactions, O RBCs (or A RBCs when anti-A is not detectable in the plasma) and AB plasma or platelets are recommended for transfusion of patients with the cis -AB phenotype in Korea [ 21 ]. In our study, Aw or Bw other than cis -AB could be easily detected by the presence of “DP” flags and a weakened reaction in forward grouping.…”

Section: Discussionmentioning

confidence: 99%

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Investigation of Discrepant ABO Blood Grouping Results from an Autoanalyzer

2022

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Background A paucity of studies evaluating failed cases of ABO grouping using autoanalyzers exists. We investigated autoanalyzer rejected cases, including serologically suspicious ABO subgroups and discrepant ABO blood grouping results from Erytra Eflexis (Grifols, Spain), to demonstrate efficient use of autoanalyzers for ABO grouping. Methods Samples requested for ABO grouping throughout 2020 were tested using two Eflexis instruments and standard ABO RhD and reverse grouping cards. Neonatal cards were not used. When necessary, a conventional tube technique (TUBE) was used to resolve rejected/discrepant Eflexis ABO grouping results. Results The overall sample rejection rate (RR) was 3.2% (628/19,466), 1.3% of which were due to various error flags and 1.9% for discrepant results. Cases from neonates ≤1 year old accounted for 35.3% of the rejected cases based on Eflexis results. The ABO groups with the highest and lowest RR (excluding neonates) were A and O, respectively. The 628 samples resulted in 682 rejections, which were frequently associated with reverse grouping, including 28.4% against A 1 and 54.5% for B red cells. Among 14 serologically weakened A and/or B blood groups, six A 2 BW and two ABw, which had been missed by Eflexis, were detected using TUBE and our follow-up laboratory criteria. Conclusions The ABO group and a proportion of neonatal samples influenced the RR due to weak reverse grouping reactivity, especially toward B red cells. Confirmatory ABO grouping by TUBE in a new patient and/or extra rejection criteria for forward grouping are needed to detect cis -AB, which is relatively common in Korea.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%