ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis

Chen, Zhuo; Yang, Shengwen; Xu, Hao; Li, Jianjun

doi:10.1038/srep23250

Cited by 102 publications

(102 citation statements)

References 33 publications

(77 reference statements)

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“…Although there is a confirmed association between ABO blood groups and CVDs and between platelet indices and thromboembolic and atherosclerotic CVD, to the best of our knowledge, there is no study that addresses the relationship between platelet indices and CVDs in healthy adults. Hence, we aimed to investigate whether MPV and PDW, two important indicators of platelet activity, had relationships with ABO blood groups in healthy adult subjects.…”

Section: Discussionmentioning

confidence: 97%

“…If the red blood cells have no A or B antigens, the blood type is called the O blood group. Many studies have investigated whether there is any relationship between ABO blood groups and cardiovascular diseases (CVDs) . Non‐O blood groups—in particular, the A blood group—were found to be associated with ischemic heart disease and atherosclerotic CVD .…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have investigated whether there is any relationship between ABO blood groups and cardiovascular diseases (CVDs) . Non‐O blood groups—in particular, the A blood group—were found to be associated with ischemic heart disease and atherosclerotic CVD . Many different studies have declared that non‐O blood groups have increased von Willebrand factor and coagulation factor VIII levels, and these increased levels could lead to cardiac and thromboembolic diseases .…”

Section: Introductionmentioning

confidence: 99%

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The relationship between platelet indices and ABO blood groups in healthy adults

Çelik

Düzenli

Aslan

et al. 2018

Clinical Laboratory Analysis

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Background ABO blood groups have been suggested to have a high correlation with cardiovascular diseases (CVDs). It has also been postulated that platelet indices, including mean platelet volume (MPV) and platelet distribution width (PDW), are very important in the development and progression of CVDs. However, despite these common associations with CVDs, as far as we know, there are no studies investigating platelet indices in ABO blood groups. Thus, the aim of this study was to investigate whether platelet indices are associated with ABO blood groups. Methods The study included 301 healthy volunteers (99 women and 202 men; mean age: 32.59 ± 7.52 years) whose blood groups were determined by the gel column method using agglutination techniques. Platelet indices were studied by an automated blood counter. Results No considerable differences in age, gender, or Rh factors were observed among ABO blood groups. MPV was detected to be considerably lower in O and A blood group subjects than in AB and B blood group subjects. Similarly, PDW was significantly lower in O and A blood group subjects than in B blood group subjects. Additionally, MPV in the O blood group subjects was significantly lower than in the non‐O blood group subjects. Conclusions Because MPV and PDW are used as markers of CVDs, individuals with O and A blood groups in this study may be considered to have a lower risk of CVDs than AB and B blood group subjects. However, prospective cohort studies involving a greater number of volunteers are needed to elucidate these relationships.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The relationship between platelet indices and ABO blood groups in healthy adults

Çelik

Düzenli

Aslan

et al. 2018

Clinical Laboratory Analysis

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“…Although several studies have been published showing the association between the inheritance of blood groups (ABO and Rh antigens) and cardiovascular diseases [8][9][10], coronary artery disease [7], ischemic heart disease (IHD) [11], however results have not been consistent. According to one study as compared to the other blood groups A blood group subjects had significantly high risk of IHD [11], while another study suggests AB blood groups reduce the risks of CHD while O blood groups raise the risks of CHD due to lower HDL-c levels [10].…”

Section: Introductionmentioning

confidence: 85%

“…In the recent past inheritance of ABO blood groups has been linked to various diseases such as diabetes [4,5] many types of cancers [6] and cardiovascular diseases [7]. Although several studies have been published showing the association between the inheritance of blood groups (ABO and Rh antigens) and cardiovascular diseases [8][9][10], coronary artery disease [7], ischemic heart disease (IHD) [11], however results have not been consistent.…”

Section: Introductionmentioning

confidence: 99%

Frequency of expression and the distribution of ABO and Rh, Blood group antigens in the myocardial infarction (MI) male Patients of the Hail region in Saudi Arabia

Farshori¹,

Alrashdan²,

Alshammari³

et al. 2017

J Integr Cardiol

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Cases of adult obesity have been rising in every age group and gender of the Saudi population. If this trend continues it can lead to drastically high incidences of diabetes and the coronary heart disease (CHD). In a recent 2014 world health survey by the WHO, Saudi Arabia was ranked 27 th in the world in CHD related deaths. Additionally in Saudi Arabia CHD was the leading cause of death in 2014. Therefore, in this study we decided to look at the possible correlation between the inheritance of blood group antigens and the high incidences of myocardial infarction (MI) among the adult male patients. Results of our study show that in the randomly selected male control group 20.7% were A + and 3.35% were A -while 14.3% were found to be B + and 3.95% were B -. AB blood group was the least prevalent blood group among the control population. Only 8.2% were found to be AB + and 2.43% were AB -. As previously reported by us and others O + blood group was the most prevalent blood group among the control population at 38.3% while only 8.5% were found to be O -. In contrast when we analyzed the blood group distribution among the 111 MI male patients our results showed a statistically significant reduction in the combined Rh -male MI patients as compared to the Rh -individuals in the control group. Additionally we found a significantly high prevalence of A + blood group (30.6%) among the MI patients as compared to the control population. Our results also showed a small but not a significant increase in B + and O + blood groups in MI patients as compared to the controls. Finally our results show statistically significant reduction in O -MI patients as compared to the control population. In conclusion A + individuals show statistically high incidences of MI and O -individuals show statistically low incidences of MI in male patients. Our results also show a statistically significant reduction in the Rh -MI patients as compared to the control group. Significance of this reduction is not clear at this time.

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Robust estimates of heritable coronary disease risk in individuals with type 2 diabetes

Grace

Hopewell

Watkins

et al. 2021

Genetic Epidemiology

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Type 2 diabetes (T2D) is an important heritable risk factor for coronary artery disease (CAD), the risk of both diseases being increased by metabolic syndrome (MS). With the availability of large‐scale genome‐wide association data, we aimed to elucidate the genetic burden of CAD risk in T2D predisposed individuals within the context of MS and their shared genetic architecture. Mendelian randomization (MR) analyses supported a causal relationship between T2D and CAD [odds ratio (OR) = 1.13 per log‐odds unit 95% confidence interval (CI): 1.10–1.16; p = 1.59 × 10−17]. Simultaneously adjusting MR analyses for the effects of the T2D instrument including blood pressure, dyslipidaemia, and obesity attenuated the association between T2D and CAD (OR = 1.07, 95% CI: 1.04–1.11). Bayesian locus‐overlap analysis identified 44 regions with the same causal variant underlying T2D and CAD genetic signals (FDR < 1%) at a posterior probability >0.7; five (MHC, LPL, ABO, RAI1 and MC4R) of these regions contain genome‐wide significant (p < 5 × 10−8) associations for both traits. Given the small effect sizes observed in genome‐wide association studies for complex diseases, even with 44 potential target regions, this has implications for the likely magnitude of CAD risk reduction that might be achievable by pure T2D therapies.

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ABO blood group system and the coronary artery disease: an updated systematic review and meta-analysis

Cited by 102 publications

References 33 publications

The relationship between platelet indices and ABO blood groups in healthy adults

The relationship between platelet indices and ABO blood groups in healthy adults

Frequency of expression and the distribution of ABO and Rh, Blood group antigens in the myocardial infarction (MI) male Patients of the Hail region in Saudi Arabia

Robust estimates of heritable coronary disease risk in individuals with type 2 diabetes

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