Abnormality Pattern of F-18 FDG PET Whole Body with Functional MRI Brain in Post-Acute COVID-19

Kiatkittikul, Peerapon; Promteangtrong, Chetsadaporn; Kunawudhi, Anchisa; Siripongsatian, Dheeratama; Siripongboonsitti, Taweegrit; Ruckpanich, Piyanuj; Thongdonpua, Supachoke; Jantarato, Attapon; Piboonvorawong, Chaiyawat; Fonghoi, Nirawan; Chotipanich, Chanisa

doi:10.1007/s13139-021-00730-6

Cited by 16 publications

(16 citation statements)

References 34 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Concerning brain metabolism, there are no headache-specific studies, but the regions most frequently reported as hypometabolic include the right parahyppocampal gyrus [ 41 ], the brainstem, thalamus, amygdala [ 41 ], orbital gyrus, olfactory gyrus, and temporal lobe [ 42 ]. One study compared images from 18-fluor-deoxy-glucose PET and functional MRI imaging, showing an overlap between the areas where the connectivity was altered in the MRI and F-18 FDG PET changes [ 43 ]. Figure 1 summarizes the main mechanisms which could be involved in the long COVID headache pathophysiology.…”

Section: Risk Factors and Pathogenesismentioning

confidence: 99%

Long COVID headache

Tana

Bentivegna²,

Cho

et al. 2022

J Headache Pain

View full text Add to dashboard Cite

Headache is among the most frequent symptoms persisting or newly developing after coronavirus disease 2019 (COVID-19) as part of the so-called long COVID syndrome. The knowledge on long COVID headache is still limited, however growing evidence is defining the features of this novel condition, in particular regarding clinical characteristics, some pathophysiological mechanisms and first treatment recommendations. Long COVID headache can present in the form of worsening of a preexisting primary headache, or, more specifically, in the form of a new (intermittent or daily) headache starting during the acute infection or after a delay. It often presents together with other long COVID symptoms, most frequently with hyposmia. It can manifest with a migrainous or, more frequently, with a tension-type-like phenotype. Persistent activation of the immune system and trigeminovascular activation are thought to play a role. As there are virtually no treatment studies, treatment currently is largely guided by the existing guidelines for primary headaches with the corresponding phenotype. The present report, a collaborative work of the international group of the Junior Editorial Board of The Journal of Headache and Pain aims to summarize the most recent evidence about long COVID headache and suggests approaches to the diagnosis and treatment of this disorder. Graphical Abstract

show abstract

Section: Risk Factors and Pathogenesismentioning

confidence: 99%

Long COVID headache

Tana

Bentivegna²,

Cho

et al. 2022

J Headache Pain

View full text Add to dashboard Cite

show abstract

“…Brain metabolic changes have been documented across multiple studies of COVID-19 patients, although with inconsistent results [17,87]. Patterns of hypo-or hypermetabolism across different cortical and subcortical symptoms are related to neuropsychiatric symptoms of the disease, including anosmia [88], fatigue [89] and cognitive impairment [17].…”

Section: Discussionmentioning

confidence: 99%

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

et al. 2022

View full text Add to dashboard Cite

People recovered from COVID-19 may still present complications including respiratory and neurological sequelae. In other viral infections, cognitive impairment occurs due to brain damage or dysfunction caused by vascular lesions and inflammatory processes. Persistent cognitive impairment compromises daily activities and psychosocial adaptation. Some level of neurological and psychiatric consequences were expected and described in severe cases of COVID-19. However, it is debatable whether neuropsychiatric complications are related to COVID-19 or to unfoldings from a severe infection. Nevertheless, the majority of cases recorded worldwide were mild to moderate self-limited illness in non-hospitalized people. Thus, it is important to understand what are the implications of mild COVID-19, which is the largest and understudied pool of COVID-19 cases. We aimed to investigate adults at least four months after recovering from mild COVID-19, which were assessed by neuropsychological, ocular and neurological tests, immune markers assay, and by structural MRI and 18 FDG-PET neuroimaging to shed light on putative brain changes and clinical correlations. In approximately one-quarter of mild-COVID-19 individuals, we detected a specific visuoconstructive deficit, which was associated with changes in molecular and structural brain imaging, and correlated with upregulation of peripheral immune markers. Our findings provide evidence of neuroinflammatory burden causing cognitive deficit, in an already large and growing fraction of the world population. While living with a multitude of mild COVID-19 cases, action is required for a more comprehensive assessment and follow-up of the cognitive impairment, allowing to better understand symptom persistence and the necessity of rehabilitation of the affected individuals.

show abstract

“…Brain metabolic changes have been documented across multiple studies of COVID-19 patients, although with inconsistent results [23, 119, 120]. Patterns of hypo-or hypermetabolism across different cortical and subcortical symptoms are related to neuropsychiatric symptoms of the disease, including anosmia [121], fatigue [122] and cognitive impairment [23].…”

Section: Discussionmentioning

confidence: 99%

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

Paula

Paiva

Silva

et al. 2022

Preprint

View full text Add to dashboard Cite

People recovered from COVID-19 may still present complications including respiratory and neurological sequelae. In other viral infections, cognitive impairment occurs due to brain damage or dysfunction caused by vascular lesions and inflammatory processes. Persistent cognitive impairment compromises daily activities and psychosocial adaptation. Some level of neurological and psychiatric consequences were expected and described in severe cases of COVID-19. However, it is debatable whether neuropsychiatric complications are related to COVID-19 or to unfoldings from a severe infection. Nevertheless, the majority of cases recorded worldwide were mild to moderate self-limited illness in non-hospitalized people. Thus, it is important to understand what are the implications of mild COVID-19, which is the largest and understudied pool of COVID-19 cases. We aimed to investigate adults at least four months after recovering from mild COVID-19, which were assessed by neuropsychological, ocular and neurological tests, immune markers assay, and by structural MRI and 18FDG-PET neuroimaging to shed light on putative brain changes and clinical correlations. In approximately one-quarter of mild-COVID-19 individuals, we detected a specific visuoconstructive deficit, which was associated with changes in molecular and structural brain imaging, and correlated with upregulation of peripheral immune markers. Our findings provide evidence of neuroinflammatory burden causing cognitive deficit, in an already large and growing fraction of the world population. While living with a multitude of mild COVID-19 cases, action is required for a more comprehensive assessment and follow-up of the cognitive impairment, allowing to better understand symptom persistence and the necessity of rehabilitation of the affected individuals.

show abstract

Abnormality Pattern of F-18 FDG PET Whole Body with Functional MRI Brain in Post-Acute COVID-19

Cited by 16 publications

References 34 publications

Long COVID headache

Long COVID headache

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings

Contact Info

Product

Resources

About