Abnormality of water barrier function in psoriasis. Role of ceramide fractions

Omega-O-Acylceramides in Skin Lipid Membranes: Effects of Concentration, Sphingoid Base, and Model Complexity on Microstructure and Permeability

“…The third permeability marker was the transmembrane water loss (Figure 3C), which was measured using an evaporimeter that is commonly used for the measurement of TEWL in vivo, but it can also be used for in vitro experiments. 47 The water loss of the control membrane was set at 100%, and the other values were normalized to the control. The presence of Cer EOS in the membranes led to higher water loss through these membranes when compared with the control with a maximum at 10% Cer EOS (37% higher than the control; the difference was not significant).…”

An Inverse Relationship Between Ceramide Synthesis and Clinical Severity in Patients with Psoriasis

“…On the other hand, the level of ceramide synthesis was significantly reduced in the lesional epidermis of patients (Table 1). These results are in concordance with the results of earlier studies in which decreases in the levels of ceramides, specifically ceramide 1, 4, and 5, have been shown to be associated with increased transepidermal water loss in the psoriatic epidermis (11). Furthermore, a positive correlation between the percentage reduction of ceramide synthesis in the lesional epidermis and clinical severity (r=0.967, p =0.0004) has been demonstrated in this study (Fig.…”

Defective barrier function accompanied by structural changes of psoriatic stratum corneum

“…Psoriasis is an inflammatory skin disease characterized by erythematous plaques and scales showing markedly defective barrier function. Previous studies showed that TEWL of psoriatic skin was increased 2–20‐fold compared with the uninvolved skin . In our study, TEWL of psoriatic skin was increased 1.7‐fold compared with the uninvolved skin confirming the previous analyses.…”