Abnormalities of p53 protein expression in cutaneous disorders

McNutt, N. Scott

doi:10.1001/archderm.130.2.225

Cited by 32 publications

(30 citation statements)

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“…[2526] If there has been the loss of an allele[22728] or the deletion of both alleles, no p53 would be produced, and the gene would therefore lose its tumor suppression function. [282930] However, not all mutant p53 genes are biologically identifiable, and there is a strong selective advantage for some mutation hotspots. [31]…”

Section: Discussionmentioning

confidence: 99%

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Reduced P53 staining in actinic keratosis is associated with squamous cell carcinoma: A preliminary study

et al. 2013

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Background:Actinic keratosis (AK) is a cutaneous neoplasm caused by prolonged sun exposure, and may progress into squamous cell carcinoma (SCC). The p53 gene plays a central role in the development of SCC, and mutations in this gene are found in 90% of SCC and up to 100% of AK cases.Objective:To identify AK cases that are highly susceptible to developing SCC.Materials and Methods:Fifty-six AK cases were classified into two groups: AK adjacent to “normal” skin and AK adjacent to SCC. The groups were compared based on epithelial atypia, inflammation, solar elastosis, histopathological AK classification and p53 protein expression.Results:Of the 56 AK cases analyzed, 23% were associated with SCC. The types of AK observed were classified as follows: common, hypertrophic, atrophic, acantholytic, pigmented and bowenoid. SCC was associated with common and hypertrophic AK, and p53 staining was observed in 78% of AK cases. The mean difference in p53 immunopositivity between common AK cases associated with SCC (17%) and not associated with SCC (45.4%) was significant (p=0.011).Conclusions:Hypertrophic and common AK are associated with SCC, and the low percentage of p53 immunopositivity in the common type indicates a greater probability of developing into SCC.

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Section: Discussionmentioning

confidence: 99%

“…[2930] However, this interpretation is unlikely to be true because the adjacent photodamaged skin from the same patient was used as a control in all of the cases studied here.…”

Section: Discussionmentioning

confidence: 99%

Reduced P53 staining in actinic keratosis is associated with squamous cell carcinoma: A preliminary study

et al. 2013

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“…It has been suggested that tumors may be unrelated to UV radiation since the TP53 staining was positive in porokeratosis of Mibelli as well as DSAP. Nevertheless, this concept brought further into question whether there was an inherited tendency to abnormal regulation or mutation of the TP53 gene in these patients [7]. Ninomiya et al [23] have shown TP53 overexpression but no TP53 gene mutation in their porokeratotic specimens.…”

Section: Discussionmentioning

confidence: 99%

“…Chromosomal instability and abnormal DNA ploidy were found in these patients [7, 8]. Also, TP53 overexpression has been reported in several types of porokeratosis (plaque, disseminated superficial actinic, disseminated superficial, linear and giant porokeratosis) [9, 10, 11, 12, 13, 14].…”

Section: Introductionmentioning

confidence: 99%

Lack of <i>TP53</i> Mutations in a Case of Porokeratosis palmaris, plantaris et disseminata

et al. 2000

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“…[1516] This tumor suppressor protein p53 has a critical role in regulation of the Bcl-2 family of proteins. [17] Under normal conditions there is no or minimal p53 expression in the sun-protected skin.…”

Section: Introductionmentioning

confidence: 99%

Expression of apoptosis regulatory markers in the skin of advanced hepatitis-C virus liver patients

et al. 2012

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Background:Hepatitis-C virus (HCV) infection is considered a major worldwide public health problem with a global prevalence. Maintenance of skin homeostasis requires a delicate balance between proliferation, differentiation, and apoptosis. Meanwhile, it is unclear if there is an altered keratinocyte proliferation/apoptosis balance in advanced liver disease with HCV infection.Aim:This work aimed to evaluate the epidermal thickness and changes in the expression of apoptosis regulatory markers as well as apoptotic index in skin samples of advanced HCV liver patients compared to normal controls.Materials and Methods:Twenty biopsies were taken from apparently normal skin of advanced HCV liver disease patients, as well as five healthy control subjects. These specimens were used for histometric epidermal measurement, immunohistochemical staining of apoptosis regulatory proteins (Bax, Fas, p53, Caspase-3, Bcl-2, Bcl-xL) as well as the TUNEL technique for detection of apoptotic cells.Results:The mean epidermal thickness was significantly lower than the control group (P=0.000). There were significant overexpression of pro-apoptotic markers (Bax, Fas, P53, and Caspase-3) in patients (P=0.03, 0.03, 0.003, 0.003 respectively), with increased apoptotic index in HCV liver patients (P=0.002) when compared to normal controls. On the other hand, no statistically significant difference were encountered in the expression of antiapoptotic markers (Bcl-2, Bcl-xL) in HCV patients when compared to normal controls (P=0.5, 0.9, respectively).Conclusion:These findings suggest that an alteration in the proliferation/apoptosis balance is present in the skin of HCV liver patients.

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Abnormalities of p53 protein expression in cutaneous disorders

Cited by 32 publications

References 0 publications

Reduced P53 staining in actinic keratosis is associated with squamous cell carcinoma: A preliminary study

Reduced P53 staining in actinic keratosis is associated with squamous cell carcinoma: A preliminary study

Lack of <i>TP53</i> Mutations in a Case of Porokeratosis palmaris, plantaris et disseminata

Expression of apoptosis regulatory markers in the skin of advanced hepatitis-C virus liver patients

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