Abnormalities in the Chemical Composition of the Skin Surface Film in Psoriasis

Rothman, Stephen

doi:10.1001/archderm.1950.01530190048004

Cited by 36 publications

(2 citation statements)

References 12 publications

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“…It has been reported that in human psoriasis the ratio of sterol ester to total sterol is low (20). Therefore, the low ratio found in the present experiment may be an indirect rather than a direct result of the EFA deficiency.…”

Section: Discussioncontrasting

confidence: 39%

Effect of essential fatty acid deficiency on lipid of skin surface of rat.

Takehisa

Kimura

1977

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryA study on how EFA deficiency affects lipid metabolism of rat skin, especially lipid on skin surface, was made.The total amount of lipid on skin surface of rat increased due to EFA deficiency, but not signi ficantly.The sterol ester in skin surface lipid was maintained at a normal level in a EFA deficient rat, but the free sterol level was higher than that of the control rat.The glycerides decreased markedly due to EFA defi ciency. It was recognized that branched fatty acids increased in each lipid fraction on skin surface.It was considered that such changes in skin surface lipid were charac teristic to skin. It was not predictable whether these changes resulted directly from EFA deficiency or secondary from the occurrence of dermal symptoms.

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Section: Discussioncontrasting

confidence: 39%

Effect of essential fatty acid deficiency on lipid of skin surface of rat.

Takehisa

Kimura

1977

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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show abstract

“…The sterol ester content of surface lipid from uninvolved psoriatic skin has been claimed to be increased (Ineedayi andOttenstein, 1941), unchanged (Marchioni et al, 1938;Wilkinson and Farber, 1967a) and decreased (Rothman, 1950;Reinertson and Wheatley, 1959). Rothman (1950) wiped skin of normal subjects and lesion free areas of psoriatic patients with cotton soaked in ether and analysed the lipid so removed. He found that in 9 normals, the percentage of cholesterol esterifled ranged from 60% to 69% whereas in seven psoriatic patients, the range extended from 35% to 60%.…”

Section: Sterols In Abnormal Keratinization: Surf Age Lipidsmentioning

confidence: 99%