Abnormal skin irritancy in atopic dermatitis and in atopy without dermatitis

Nassif, A.

doi:10.1001/archderm.130.11.1402

Cited by 66 publications

(44 citation statements)

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“…res. 51 (2002) 483 -489 1023-3830/02/100483-07 stimuli including toxic chemicals and contact allergens are postulated to initiate contact dermatitis through modulation of epidermal keratinocytes [8][9][10], and thereby amplify the inflammatory response in atopic dermatitis and psoriasis [11][12][13][14][15][16]. We reported previously that topical vitamin E alleviated skin irritation induced by a transdermal absorption enhancer and that its possible mechanism was the inhibition of keratinocyte-modulation but not of the catalyzing action of O 2 - [17].…”

Section: Introductionmentioning

confidence: 99%

Vitamin E ointment at high dose levels suppresses contact dermatitis in rats by stabilizing keratinocytes

et al. 2002

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Section: Introductionmentioning

confidence: 99%

Vitamin E ointment at high dose levels suppresses contact dermatitis in rats by stabilizing keratinocytes

et al. 2002

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“…First, atopic volunteers were chosen as test subjects. There are indications that atopics are more reactive to irritants than non-atopics [9, 10, 11]. Secondly, the rubbing of the skin with fabric was intended to simulate a realistic, worst-case situation.…”

Section: Discussionmentioning

confidence: 99%

“…As atopic skin is already compromised, it could be more sensitive to further insult by irritants than normal skin of the general population [9, 10, 11]. It is therefore reasonable to suppose that any skin irritation effects expected from the use of a certain product should be more easily identified with a panel of atopic volunteers.…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Softened Fabrics on Atopic Skin

et al. 2001

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There is general concern about the possible cutaneous adverse effects of wearing garments treated with household laundry products, particularly on atopic skin. Our objective was to compare softened and non- softened fabrics in a forearm wet and dry test, under conditions simulating real-life conditions. Twenty atopic volunteers entered a single-blind 12-day (3 sessions per day) forearm wetting and drying test. Cotton fabrics were machine washed and liquid fabric conditioner was added or not to the final rinse. To simulate conditions of skin damage, a dilute solution of sodium lauryl sulphate was applied under occlusion to the forearm of each volunteer before the start of the study. Skin effects were evaluated by visual grading (redness, dryness and smoothness), squamometry and in vivo instrumental measurements (capacitance, transepidermal water loss and colorimetry). Rubbing of atopic skin with fabrics generally resulted in discrete to moderate alterations of the structure of the stratum corneum. Both for control and pre-irritated skin, all measured parameters indicated that softened fabric was less aggressive to the skin than unsoftened fabric. In the case of pre-irritated skin, the recovery of the skin was significantly faster when rubbed with softened than with unsoftened fabrics. In conclusion, softened fabrics help mitigate the skin condition in atopic patients.

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“…Firstly, there is an increased reaction of dermis to irritant agents in atopic children, so a PPD reaction may also have increased as well. Accordingly, Nasif et al [31] showed that allergic individuals presented an excessive response against irritant agents. In our study, excessive reactions were not seen in the study group to such an irritant agent like physiological saline.…”

Section: Introductionmentioning

confidence: 99%

Is the Mycobacteria-Derived Purified Protein Response in Atopic Asthmatic Children Different?

Kale

Taştan

Pinçe

et al. 2004

Int Arch Allergy Immunol

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Background: The response to mycobacteria-derived purified protein (PPD) is mediated primarily by T-helper-1 response and is expected to be inhibited in atopic diseases. The aim of this study was to investigate whether the PPD response is different in atopic asthmatic children. Methods: 40 atopic asthmatic children (mean age 8.3 ± 4.9 years) and 40 healthy age- and sex-matched children who had received bacillus Calmette-Guérin (BCG) vaccination were included in the study. Five PPD units were administered intradermally to all children and were interpreted after 48 h. Results: There was no correlation between serum total IgE level and PPD induration (p = 0.054). The PPD induration was not statistically different between the children who used inhaled corticosteroid and those who did not. Although the PPD positivity (induration ≧5 mm) rate was higher in atopic asthmatic children (50%) than in healthy children (32.5%), the difference was not found to be statistically significant. The PPD induration in atopic asthmatic children (7.41 ± 5.58 mm) was found to be greater than the one in healthy children (5.21 ± 3.39) (p < 0.039). The induration in atopic asthmatic children (5.21 ± 3.77) and healthy children (4.43 ± 2.32) did not show a difference in children who where vaccinated only once with BCG, but it was found to be statistically significantly greater in atopic asthmatic children (12.50 ± 5.90) than healthy children (7.08 ± 4.70) who were vaccinated with BCG twice (p < 0.012). The proportion of having a PPD induration of ≧10 mm was found to be higher in atopic asthmatic children than in the healthy ones (32.5 vs. 12.5%) (p < 0.032). Conclusion: Our data showed that the PPD response was stronger in BCG-vaccinated atopic asthmatic children than in healthy BCG-vaccinated ones.

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Abnormal skin irritancy in atopic dermatitis and in atopy without dermatitis

Cited by 66 publications

References 0 publications

Vitamin E ointment at high dose levels suppresses contact dermatitis in rats by stabilizing keratinocytes

Vitamin E ointment at high dose levels suppresses contact dermatitis in rats by stabilizing keratinocytes

Beneficial Effects of Softened Fabrics on Atopic Skin

Is the Mycobacteria-Derived Purified Protein Response in Atopic Asthmatic Children Different?

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